Mighty Mutanimals, a superhero group within the Teenage Mutant Ninja Turtles (TMNT) franchise, emerged in the comic-book series Teenage Mutant Ninja Turtles Adventures. Composed of various mutated animals, the team collaborated with the TMNT and has been featured in multiple iterations of the franchise since its inception.

Mighty Mutanimals was first published as a three-issue miniseries released between May and July 1991, which was later released in a collection in Winter 1991. A follow-up regular series totaling nine issues was released from April 1992 until June 1993.

The series was canceled due to low sales, but the Mutanimals received their own 7-part backup-series in the pages of Teenage Mutant Ninja Turtles Adventures beginning in issue #48 and ending in issue #54. This series saw the assassination of the Mutanimals at the hands of the high-tech Gang of Four. Issues #55-57 continued the aftermath of their death and its effect on the Turtles' storyline. The proposed animated series was meant to take place during the 1987 series, where they are a team of superheroes that go around the world to fight evil. The turtles were meant to be shown up at the beginning of the series to help set up the island base HQ and once they are finishing it the turtles will return to New York leaving the Mutanimals to start becoming heroes in their own right and begin their own adventures.

The Mutanimals made a small cameo appearance in Tales of the TMNT #58. Dean Clarrain, Ken Mitchroney, Mike Kazaleh, and Garrett Ho all worked on the comic book miniseries.

Though the team was called "Mutanimals", implying that the members were all "mutant animals", only three were "true" mutants: Ray Fillet, Mondo Gecko, and reserve member Merdude. Leatherhead (Archie's version) was a magically transformed human and so was Dreadmon, who was more or less a werewolf created by voodoo. Wingnut, Screwloose and Slash (Archie's version), were all aliens from Dimension X, and Jagwar was a demigod son of a human mother and jaguar spirit/god.

A new version of the Mutanimals also appears in the Teenage Mutant Ninja Turtles IDW Comic series, in which Mondo Gecko, Man Ray and Slash reprise their roles as part of its membership. While Old Hob served as its leader, exclusive to this group are Herman the Hermit Crab, Pigeon Pete, and a mutant lioness named Sally Pride as well as a new interpretation of the Fred Wolf animated series character Mutagen Man.

This version was created when Slash and Old Hob abduct former StockGen scientist Lindsey Baker and hire her to help them create a more coherent mutant army to protect the other mutants of New York City, since their own try at it resulted in Pigeon Pete who isn't at all that bright. Hob had obtained a large canister of mutagen and samples of Splinter's blood (containing the missing psychotropic compound). Slash willingly injects himself with some of Splinter's blood and the compound within makes Slash intelligent in moments, proving her theory correct. Lindsey then uses a gecko and hermit crab stolen by Hob and Slash to create Mondo Gecko and Herman, having successfully combined the compound with the mutagen. Old Hob later gained the services of Sally Pride, Man Ray, and Mutagen Man, mutants created by the Null Group as slaves.

When Old Hob detonates a Mutagen bomb following Baxter Stockman becoming the Mayor of New York City causing anyone who was mutated to be placed in Mutant Town, Old Hob establishes a tight-fisted regime in the ghetto, hiring a number of mutants as his Mutanimal Enforcers, and surreptitiously starts selling some mutants to Karai in return for vital supplies. Upon learning this, Sally renounces her allegiance with Hob, sides with the Ninja Turtles and runs for the position as Mutant Town's first mayor. During a public rally, an attempt by Man Ray on Sally's life - an action not sanctioned by Hob - causes the Mutant Towners to rise against Hob's regime, toppling him and forcing him underground.