Mildew resistance locus o

Mildew locus o (MLO) is a plant-specific gene family. Specific members of the Mildew Locus O gene family act as powdery mildew susceptibility factors. Their inactivation, as the result of a loss-of-function mutation, gene knock-out, or knock-down, is associated with a peculiar form of resistance, referred to as mlo resistance.^[1][2] The mlo gene family is widely conserved across the plant kingdom with some members evolving as early as the first land plants.^[3] Mlo proteins contain seven highly conserved transmembrane domains, as well as a calmodulin-binding domain.^[1] TaMLO genes are the MLOs in bread wheat, Triticum aestivum.^[4]

1. ^ ^{a b c d} "Genome-wide analysis of the mildew resistance locus o (MLO) gene family in tomato (Solanum lycopersicum L.)" (PDF). Plant Omics Journal. Retrieved 2020-10-19.
2. ^ Iovieno, Paolo; Andolfo, Giuseppe; Schiavulli, Adalgisa; Catalano, Domenico; Ricciardi, Luigi; Frusciante, Luigi; Ercolano, Maria Raffaella; Pavan, Stefano (2015). "Structure, evolution and functional inference on the Mildew Locus O (MLO) gene family in three cultivated Cucurbitaceae spp". BMC Genomics. 16: 1112. doi:10.1186/s12864-015-2325-3. PMC 4696115. PMID 26715041.
3. ^ Kusch, Stefan; Pesch, Lina; Panstruga, Ralph (2016). "Comprehensive Phylogenetic Analysis Sheds Light on the Diversity and Origin of the MLO Family of Integral Membrane Proteins". Genome Biology and Evolution. 8 (3): 878–895. doi:10.1093/gbe/evw036. PMC 4824068. PMID 26893454. Retrieved 11 January 2021.
4. ^ Li, Shaoya; Zhang, Chen; Li, Jingying; Yan, Lei; Wang, Ning; Xia, Lanqin (2021). "Present and future prospects for wheat improvement through genome editing and advanced technologies". Plant Communications. 2 (4) 100211. CAS Center for Excellence in Molecular Plant Sciences + Chinese Society for Plant Biology (Cell Press). doi:10.1016/j.xplc.2021.100211. ISSN 2590-3462. PMC 8299080. PMID 34327324.

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