Mingo Junction is a village in Jefferson County, Ohio, United States, along the Ohio River. The population was 3,347 at the 2020 census. It is part of the Weirton–Steubenville metropolitan area.

The Mingo people once had a settlement at the location of the present-day village, which is the source of its name. Originally known as Mingo Bottom or Mingo Town, it was the starting point for the ill-fated Crawford expedition against Native Americans in 1782, during the American Revolutionary War.

In 1770, George Washington set out on an expedition to explore the Ohio River Valley. On October 22, he camped overnight in what was known then as Mingo Town, describing it as blustery and cold with about 20 cabins and 70 inhabitants of the Iroquois Confederation. Washington wrote a complete account of his observations in a diary stored in the Library of Congress.

Mingo Junction was founded circa 1869 when an iron works was started there. In 1900, its only manufacturing plant was a steel mill owned by Carnegie Steel Company.

Mingo Junction is in the Eastern time zone. According to the United States Census Bureau, the village has a total area of 2.86 square miles (7.41 km²), of which 2.69 square miles (6.97 km²) is land and 0.17 square miles (0.44 km²) is water.

Altamont, Churchill, Hillsboro, Hunky Hill, North Hill, Sunrise Terrace, Downtown (Commercial Ave.), and Goulds Deandale Georges Run

As of the 2020 census, Mingo Junction had a population of 3,347. The median age was 43.5 years. 20.3% of residents were under the age of 18 and 21.3% of residents were 65 years of age or older. For every 100 females there were 92.5 males, and for every 100 females age 18 and over there were 92.2 males age 18 and over.

100.0% of residents lived in urban areas, while 0.0% lived in rural areas.