Mir-451 microRNA

mir-451
mir-451
	miR-451 microRNA secondary structure and sequence conservation
Identifiers
Symbol	mir-451
Rfam	RF00722
miRBase family	MIPF0000148
OMIM	612071
Other data
RNA type	microRNA
Domain(s)	Eukaryota; Vertebrata
PDB structures	PDBe

In molecular biology mir-451 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-451 regulates the drug-transporter protein P-glycoprotein, potentially promoting resistance to the chemotherapy drug Paclitaxel.^[1]

Applications

A proof-of-concept experiment has shown that miR-451, as well as mir-126 and mir-150, could be using in forensic science to distinguish between blood and saliva samples.^[2] This is made possible by different miRNA profiles of miRNAs in the different tissue types.^[2]

References

^ van Jaarsveld, MT; Helleman, J; Berns, EM; Wiemer, EA (August 2010). "MicroRNAs in ovarian cancer biology and therapy resistance". The International Journal of Biochemistry & Cell Biology. 42 (8): 1282–1290. doi:10.1016/j.biocel.2010.01.014. PMID 20083225.
^ ^a ^b Courts, C; Madea, B (Aug 9, 2011). "Specific Micro-RNA Signatures for the Detection of Saliva and Blood in Forensic Body-fluid Identification". Journal of Forensic Sciences. 56 (6): 1464–1470. doi:10.1111/j.1556-4029.2011.01894.x. PMID 21827476. S2CID 41948164.

Yang JS, Maurin T, Robine N, Rasmussen KD, Jeffrey KL, Chandwani R, Papapetrou EP, Sadelain M, O'Carroll D, Lai EC (2010). "Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis". Proc Natl Acad Sci U S A. 107 (34): 15163–15168. Bibcode:2010PNAS..10715163Y. doi:10.1073/pnas.1006432107. PMC 2930549. PMID 20699384.
Yu D, dos Santos CO, Zhao G, Jiang J, Amigo JD, Khandros E, Dore LC, Yao Y, D'Souza J, Zhang Z, Ghaffari S, Choi J, Friend S, Tong W, Orange JS, Paw BH, Weiss MJ (2010). "miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta". Genes Dev. 24 (15): 1620–1633. doi:10.1101/gad.1942110. PMC 2912560. PMID 20679398.
Patrick DM, Zhang CC, Tao Y, Yao H, Qi X, Schwartz RJ, Jun-Shen Huang L, Olson EN (2010). "Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta". Genes Dev. 24 (15): 1614–1619. doi:10.1101/gad.1942810. PMC 2912559. PMID 20679397.
Godlewski J, Bronisz A, Nowicki MO, Chiocca EA, Lawler S (2010). "microRNA-451: A conditional switch controlling glioma cell proliferation and migration". Cell Cycle. 9 (14): 2742–2748. doi:10.4161/cc.9.14.12248. PMID 20647762.
Svasti S, Masaki S, Penglong T, Abe Y, Winichagoon P, Fucharoen S, Umemura T (2010). "Expression of microRNA-451 in normal and thalassemic erythropoiesis". Ann Hematol. 89 (10): 953–958. doi:10.1007/s00277-010-0980-7. PMID 20461517. S2CID 35296680.
Godlewski J, Nowicki MO, Bronisz A, Nuovo G, Palatini J, De Lay M, Van Brocklyn J, Ostrowski MC, Chiocca EA, Lawler SE (2010). "MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells". Mol Cell. 37 (5): 620–632. doi:10.1016/j.molcel.2010.02.018. PMC 3125113. PMID 20227367.
Bruchova-Votavova H, Yoon D, Prchal JT (2010). "miR-451 enhances erythroid differentiation in K562 cells". Leuk Lymphoma. 51 (4): 686–693. doi:10.3109/10428191003629362. PMID 20218812. S2CID 36579523.
Tsuchiya S, Oku M, Imanaka Y, Kunimoto R, Okuno Y, Terasawa K, Sato F, Tsujimoto G, Shimizu K (2009). "MicroRNA-338-3p and microRNA-451 contribute to the formation of basolateral polarity in epithelial cells". Nucleic Acids Res. 37 (11): 3821–3827. doi:10.1093/nar/gkp255. PMC 2699527. PMID 19386621.
Bandres E, Bitarte N, Arias F, Agorreta J, Fortes P, Agirre X, Zarate R, Diaz-Gonzalez JA, Ramirez N, Sola JJ, Jimenez P, Rodriguez J, Garcia-Foncillas J (2009). "microRNA-451 regulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells". Clin Cancer Res. 15 (7): 2281–2290. doi:10.1158/1078-0432.CCR-08-1818. PMID 19318487.
Pase L, Layton JE, Kloosterman WP, Carradice D, Waterhouse PM, Lieschke GJ (2009). "miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2". Blood. 113 (8): 1794–1804. doi:10.1182/blood-2008-05-155812. PMC 2647672. PMID 18849488.
Gal H, Pandi G, Kanner AA, Ram Z, Lithwick-Yanai G, Amariglio N, Rechavi G, Givol D (2008). "MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells". Biochem Biophys Res Commun. 376 (1): 86–90. doi:10.1016/j.bbrc.2008.08.107. PMID 18765229.
Kovalchuk O, Filkowski J, Meservy J, Ilnytskyy Y, Tryndyak VP, Chekhun VF, Pogribny IP (2008). "Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin". Mol Cancer Ther. 7 (7): 2152–2159. doi:10.1158/1535-7163.MCT-08-0021. PMID 18645025.
Zhu H, Wu H, Liu X, Evans BR, Medina DJ, Liu CG, Yang JM (2008). "Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells". Biochem Pharmacol. 76 (5): 582–588. doi:10.1016/j.bcp.2008.06.007. PMC 2628586. PMID 18619946.

External links

Page for mir-451 microRNA precursor family at Rfam
"MicroRNA MIR451 family (MIR451) Gene group". HUGO Gene Nomenclature Committee (HGNC).

This genetics article is a stub. You can help Wikipedia by expanding it.

[1] van Jaarsveld, MT; Helleman, J; Berns, EM; Wiemer, EA (August 2010). "MicroRNAs in ovarian cancer biology and therapy resistance". The International Journal of Biochemistry & Cell Biology. 42 (8): 1282–1290. doi:10.1016/j.biocel.2010.01.014. PMID 20083225.

[Cou11-2] Courts, C; Madea, B (Aug 9, 2011). "Specific Micro-RNA Signatures for the Detection of Saliva and Blood in Forensic Body-fluid Identification". Journal of Forensic Sciences. 56 (6): 1464–1470. doi:10.1111/j.1556-4029.2011.01894.x. PMID 21827476. S2CID 41948164.

[1]

[2]

v t e miRNA precursor families
1-100	1 2 3 5 6 7 8/141/200 9/79 10 11 14 15 16 17 19 21 22 23 24 25 26 28 29 30 31 32 33 34 42 46/47/281 48 52 58 61 62 67 71 84 92 96
101-200	101 103/107 122 124 126 127 129 130 132 133 134 135 137 138 141 143 144 145 146 148/152 150 153 154 155 156 160 166 172 181 184 185 186 187 188 190 191 192/215 193 194 196 198 199 200
201-300	202 203 203a 205 208 210 212 214 216 218 219 221 223 224 241 275 277 278 279 281 282 296 299
301-400	301 305 322 326 330 331 337 338 339 340 344 345 346 350 351 361 363 365 367 370 374 383 384 390 394 395 396 397 398 399
401-500	403 408 423 425 430 431 432 433 434 444 448 449 451 452 454 455 474 484 488 489 491 492 497 498 500
501-600	503 504 505 506 529 535 541 542 544 548 549 550 552 558 562 569 572 575 580 584 589 590 592 598
601+	601 605 612 615 612 612 624 625 632 633 636 638 650 652 657 661 663 671 672 675 708 711 720 744 764 765 767 786 802 824 828 854 872 873 874 885 938 939 3180
Other	BART1 BART2 BHRF1-1 BHRF1-2 BHRF1-3 Let-7 Lin-4 Lsy-6

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