Mission San Jose High School (MSJHS or MSJ) is a four-year co-educational public high school founded in 1964. It is located in the Mission San Jose district of Fremont, California, United States. It is one of five comprehensive high schools in the Fremont Unified School District. Mission San Jose High School is the third largest high school in Fremont. It was named after Mission San José de Guadalupe, the 1797 Spanish church founded nearby.

In 2023, U.S. News & World Report ranked Mission San Jose High as the 80th best high school in the United States. The school was ranked 8th in California, with an Advanced Placement participation rate of 91%.

The school was named a National Blue Ribbon School in 1987, 1996, and 2008.^{[citation needed]}

As of the 2023–24 school year, 89.8% of the students were Asian American, 4.5% were European American, 3.2% were Hispanic and 0.3% were African American. According to California School Dashboard, in 2017 MSJHS had 3.8% socioeconomically disadvantaged students and 3.1% English Learners out of its total population of 2003.

In 2008, Mission San Jose's National Ocean Science Bowl Team placed first at the regional competition, advancing to the National Competition and placing second behind Lincoln-Sudbury Regional High School.

In 2015, Mission San Jose's Ocean Science Bowl team finished fourth in the nationals; they attended the nationals again in 2017.

In 2022, Mission San Jose's Science Bowl team finished second in Nationals.

In 2023, 2024, 2025 Mission San Jose's Science Bowl team won Regionals and qualified for Nationals.