A Mississippi Landmark is a building officially nominated by the Mississippi Department of Archives and History and approved by each county's chancery clerk. The Mississippi Landmark designation is the highest form of recognition bestowed on properties by the state of Mississippi, and designated properties are protected from changes that may alter the property's historic character. Currently there are 890 designated landmarks in the state. Mississippi Landmarks are spread out between eighty-one of Mississippi's eighty-two counties; only Issaquena County has no such landmarks.

In October 2011, the Mississippi Department of Archives and History removed the .pdf listing from its website, adding a searchable database that is kept up-to-date as new landmarks are designated. This database contains information about many historic buildings in Mississippi, but to return a list of designated Mississippi Landmarks, click the "MS Landmarks" link and enter desired city or county.

Following are the properties listed as landmarks by the Mississippi Department of Archives and History as of August 2009.