Moore Haven is a city in, and the county seat of, Glades County, Florida, United States. It is part of the Florida Heartland region. The population was 1,566 at the 2020 census, down from 1,680 at the 2010 census. Moore Haven is located on the southwest shoreline of Lake Okeechobee. It is part of the Clewiston, Florida Micropolitan Statistical Area (μSA).

The City of Moore Haven was named after James A. Moore (1861-1929), its founder. In its early days, Moore Haven was often called "Little Chicago", reflecting its status as a significant boom town. It was ideally located at the apex of Lake Okeechobee and the Caloosahatchee Canal.

In 1917, Marian Newhall Horwitz was elected as, not only the first woman mayor of Moore Haven, or the first woman mayor in Florida, she was additionally, the first female mayor south of the Mason-Dixon line.

Horwitz was described by the Moore Haven Times, in a July 27, 1917 issue, as being "business from head to foot" along with being seen regularly at 5:15 am riding horseback to work. She resigned on June 22, 1918, taking over management of the Desoto Land Company after her second husband, John J. O'Brien, left to serve in World War I, and after her decision to live on the farm, outside the city limits.

After stepping down as mayor, a "grateful citizenry" gave her a silver trophy, which was eventually passed to her son, Dr. Orville Horwitz, as of 1985.

Horwitz is credited with bringing the railroad to Moore Haven, while her brother was a business associate of J.P. Morgan, the vice-president of the Atlantic Coastline Railroad.

In 1918, construction of the first extension line was finished, bringing Moore Haven's first train on May 13, 1918. The twenty passengers and fifteen freight cars arrived ninety minutes late. "Late arrivals, unannounced schedule changes, and faulty equipment, as well as derailments, were to plague the railroad from the start." The train was often called the "Hinky Dink" and the "Muck Special." In addition to nicknames, a well-known joke about the train circulated, too, "a middle-aged man, who got off the train at Moore Haven, had left Haines City, as a young boy, in the care of the conductor."

The Great Miami Hurricane of 1926 dramatically altered the landscape of the area. The storm surge from the lake caused widespread death and destruction, sometimes literally relocating houses to the opposite side of the river. The town might have recovered, but it was hit not long after by the 1928 Okeechobee Hurricane. This decimated areas that had escaped damage in 1926.^{[citation needed]}