Motile sperm domain containing 3 is a protein that in humans is encoded by the MOSPD3 gene.

This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.