Mrs. Sam Houston House is a historic house on Farm to Market Road 390 in Independence, Texas. Sometimes known as the Root house, this Greek Revival house was built probably around 1855. Margaret Lea Houston, the widow of politician and Texas statesman Sam Houston, bought the house in 1864 from Major Eber Cave, a family friend. She lived in it during her final years until her death in 1867. The property was listed on the National Register of Historic Places in 1970 as the "Mrs. Sam Houston House," notable for its association with her.

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