Muir College is a semi-private English medium high school for boys situated in the suburb of Vanes Estate in Kariega (Nelson Mandela Bay Metropolitan Municipality) in the Eastern Cape province of South Africa. Muir caters for pupils from Grades 4 to 12. It is one of the oldest schools in South Africa (SA) established in 1822.

Muir College is one of the oldest boys english' speaking high school in South Africa, possibly tracing its origins back to 1822 when a Scottish educationalist, James Rose Innes MA (King's College, Aberdeen), established Uitenhage's first Free Government School in Cuyler Street on 12 October, with 60 pupils. Admission was open to all children, irrespective of gender, ethnicity or economic status, and by 1829 enrolment had increased to 167. Innes resigned in 1830 to take up the position of Professor of Mathematics at the South African College in Cape Town, and in 1839 became the first Superintendent-General for Education in the Cape. In 1865 the Uitenhage Proprietary School – a private, fee-paying school - opened in Uitenhage with the Rev Dr Robert Templeton MA (Glasgow) as its first headmaster.

In 1873 the Government School and the Proprietary School amalgamated to form the Undenominational Public School, and in 1875 the school moved to new purpose-built premises on the corner of Cannon Street and Park Avenue. In 1892 the school's name was changed to the Muir Academy in honour of the new Superintendent-General of Education in the Cape, Dr (later Sir) Thomas Muir MA, HonLLD (Glasgow).

In 1904 a new, red-brick school building designed by celebrated architect William White-Cooper was opened on the Park Avenue site by Dr[doctor] Muir. By this time the school was officially 'Muir High School', but by 1907 it was universally known as 'Muir College'. In 1962 the college was split to create Muir College Boys' Primary School (housed in the college buildings on the south side of Cannon Street), and Muir College Boys' High School (housed in the red-brick buildings in Park Avenue).

In 1987 the high school moved to a new, very spacious campus in Vanes Estate, and Muir Primary moved into the Park Avenue buildings. The Senior and Primary schools were reunited in 1994 and currently occupy the Vanes Estate site where there are extensive sports facilities as well as boarding facilities for approximately 100 pupils.

Origin Of The School Badge: The school badge had its origin in the Proprietary School, and shows the rampant lion of Scotland in the left quadrant, honouring the first (Scottish) headmaster. Facing it is a cross taken from Uitenhage's coat of arms (from the family crest of the founder of Uitenhage, General J Uitenhage de Mist.) Below is a Xhosa warrior, representing the Eastern Cape, which also appears on the seal of the proposed Eastern Cape Colony. Although the division of the Cape Colony into East and West did not occur, a seal was prepared and is on view in the Cuyler Manor Museum. The last quadrant shows an anchor, representing the Cape Colony.

"Nec Pluribus Impar", Latin for "Second to None"

Stand and sing for auld lang syne,
Shout till the rafters ring.
Stand and sing our song once again,
Let every loyal heart now sing.
Then think of all the happy hours,
Think of the careless days.
Think of all who went before us,
Yet linger in our thoughts always.

Let us sing to the Muir,
To the school with the glorious memories,
To the men of the past, and the name they have handed down to us;
To the life and the strife, in the games that are stirring and calling us;
Carry on! Carry on! Carry on the good name of the Muir!

So - Stand and sing for auld lang syne,
Shout till the rafters ring.
Stand and sing our song once again,
Let every loyal heart now sing.
Then think of all the happy hours,
Think of the careless days.
Think of all who went before us,
Yet linger in our thoughts always