NFL Primetime is a sports television program that has aired on ESPN since 1987. The show is presented similarly to ESPN's own SportsCenter, featuring scores, highlights, and analysis of every game of the week in the NFL.

When it debuted in 1987, the show aired every Sunday night during the NFL season. When NBC acquired the rights for Sunday night games beginning in the 2006, NBC also negotiated for exclusive rights for extended highlights during its Football Night in America pregame show, causing ESPN to begin airing NFL Primetime on Mondays. In 2019, the program was moved to ESPN+.

Until the 2006 season, NFL Primetime aired every Sunday night during the NFL season and it preceded ESPN's coverage of Sunday Night Football (it even aired when ESPN did not have a Sunday night game, especially from 1990 to 1997 when TNT had Sunday night games the first half of the season). The show was hosted by Chris Berman, with analysis from Tom Jackson. Berman and Jackson recapped Sunday afternoon's NFL games with highlights, statistics, and commentary.

Pete Axthelm was a regular from 1987 until his death in 1991. Through the show's history, other co-hosts included John Saunders, Robin Roberts, Bill Pidto, and Stuart Scott. Pidto was often the target of good-natured ribbing by Berman, since Pidto often did recaps of games featuring losing teams. Roberts also seemed to be assigned to recap almost every game the Tampa Bay Buccaneers played between 1990 and 1992, when the Bucs were fielding some of the worst teams in NFL history. The position of co-host was dropped prior to the start of the 1998 season.

During the first three rounds of the playoffs, a half-hour edition of NFL Primetime would air after the competition of each night's games. A guest analyst typically joined Jackson on the panel, while a co-host was deemed unnecessary since Berman would only need to recap only two games on those nights. An extended edition of NFL Primetime would then air after each Super Bowl at the game's site, serving as ESPN's postgame show with player interviews.

Rather than provide the usual package of scoring highlights, NFL Primetime presented extended highlights which also showed less dramatic plays. This provided context for the greater depth of analysis of each game. A common non-dramatic play that would be shown would be a game-clinching first down while a team was running out the clock. Some of the less dramatic plays would be used to demonstrate an overall large accomplishment. During the highlights for the Chicago Bears-San Francisco 49ers matchup in 2000, when Terrell Owens broke an NFL record by catching 20 passes in a game (since broken by Brandon Marshall), all 20 of Owens's receptions were shown. Other examples involved seemingly unsuccessful plays ultimately benefitting a team. For the highlights of the Buccaneers-Miami Dolphins game in 2000, a contest marred by heavy rains which came down to the final minute, a play where Bucs running back Warrick Dunn broke a tackle in his own end zone to avoid a safety was shown to demonstrate it as one of the biggest plays contributing to the Bucs's victory.

The show began with Berman welcoming viewers and then giving a quick rundown of the late games before beginning the highlights of the early games. They were generally shown in a relatively chronological order, with the 1:00 games shown first and the 4:00/4:15 games shown near the end of the program. However, on some occasions (particularly in Week 17 when teams would be making their final push for the playoffs), the highlights would be presented less chronologically. For Week 17 games, the highlights would instead be sorted by conference, with teams competing against each other for a playoff spot or a division title shown back-to-back. Probably the show's most notable occurrence with this scenario came in Week 17 of the 1999 season, when the Green Bay Packers and Carolina Panthers tied in overall record, division record, conference record, and common opponent record, meaning that a spot involving the two teams would come down to point differential. As a result, both teams ran up the score against their opponents in their final games in order to try to outscore the other team in the race. For this scenario, the Arizona Cardinals-Packers and the New Orleans Saints-Panthers highlights were shown simultaneously, with scoring by the teams in both games shown chronologically while a graphic would be shown featuring which team was leading at the time based on point differential. When ESPN aired the Sunday Night game, the broadcast usually featured a preview of that game. Later airings of NFL Primetime featured a SportsCenter highlight of that game.

Starting in 2003, a game with either high stakes for both teams or an exciting finish (typically a 1:00 game) would be chosen by Berman, Jackson, and their staff as that week's "Prime Cut." This game would be shown in the middle of the program with an extended lead-in by Berman. Also in 2003, a segment entitled "T.J.'s Extra Point" was introduced, where Jackson would demonstrate greater analysis over a strategy a team used to great success. At the end of the show, a segment entitled "Primetime Players" would feature both Berman and Jackson choosing a player or team unit that particularly impressed them from that week's games. At the turn of the millennium, a fan vote for that week's primetime player would also be conducted for the show on ESPN's website.