Natick High School is an urban/suburban public high school serving students in grades 9 to 12 in Natick, Massachusetts, United States. The school is located on the banks of Dug Pond. Its enrollment was 1,753 students during the 2025–2026 school year. The original building was built in 1953 at approximately 189,000 sq ft (17,600 m²). and opened in 1954. The building was expanded in 1965 (additional 94,000 sq ft.). Additional renovations took place in 1985. In 2010, the town voted to replace the Natick High School building. The new facility was constructed on the fields immediately to the south of the former building. Demolition on the former building began on June 25, 2012. The new building design is based on a model approved by the state of Massachusetts. This was necessary in order to maximize state reimbursement for design and construction; it cost $78 million. The new high school opened to students on August 29, 2012.

Notable alumni of Natick High's theatre program, speech team, and music programs include William Finn, Alison Fraser, Jonathan Richman, and Marc Terenzi.

The Sassamon was the school newspaper that was published four times a year, in December, February, April, and June. It eventually became the annual yearbook. The Sassamon was named after John Sassamon, the Native American aid of John Eliot (missionary). Currently, Natick High's newspaper is The Natick Nest, named after the school's nickname, the Redhawk. The Natick Nest is published 6 times a year.

42°16′28.91″N 71°21′42.36″W / 42.2746972°N 71.3617667°W / 42.2746972; -71.3617667