National Yang Ming Chiao Tung University (Chinese: 國立陽明交通大學; NYCU) is a public research university located in East District, Hsinchu City, Taiwan. It was established on February 1, 2021, through the merger of National Chiao Tung University (originally founded in 1896, re-established in Taiwan in 1958) and National Yang-Ming University (founded in 1975). NYCU offers a comprehensive range of academic disciplines across the fields of science and engineering, medicine, and the humanities, and is organized into 20 colleges.

National Yang Ming Chiao Tung University (NYCU) is headquartered at the Guangfu Campus [zh] in Hsinchu. The university operates with a dual main campus system: the Guangfu Campus in Hsinchu and the Yangming Campus [zh] in Taipei. NYCU also maintains several other campuses, including the Beimen Campus [zh] in Taipei, the Liujia [zh] and Bo’ai Campuses [zh] in Hsinchu, the Tainan Campus [zh], and the Lanyang Campus [zh] in Yilan, which houses the NYCU hospital [zh]. Including planned expansions in Shilin, Taipei, and Qingpu, Taoyuan, NYCU’s campus network spans ten locations across six cities and counties in Taiwan.

National Yang Ming Chiao Tung University (NYCU) is one of four universities—along with National Taiwan University, National Cheng Kung University, and National Tsing Hua University—selected by the Ministry of Education for the Globalink Program under the Higher Education SPROUT Project. NYCU is also a member of the University System of Taiwan (UST), which includes National Tsing Hua University, National Central University, and National Chengchi University.

The idea of merging National Yang Ming Chiao Tung University (NYCU) can be traced back to 1998–2000, although the earliest initiative toward integration was led by National Tsing Hua University (NTHU). At the time, National Yang-Ming University (NYMU), Taipei Veterans General Hospital, and NTHU had already established long-standing collaborations in biomedical research. In 1998, then-NYMU President Luke S. Chang proposed the concept of a university merger to NTHU President David Chung-Laung Liu.

On November 24, 1999, NTHU formally established a merger task force, led by Vice President Chen Hsin-Hsiung. Meanwhile, National Taiwan University (NTU) was planning to establish a hospital in Zhubei, sparking intense public discussion about healthcare accessibility in the Hsinchu area and creating a biomedical science park.

Given that neither NTHU nor National Chiao Tung University (NCTU) had a medical school, and that NYMU was also interested in establishing a hospital, former NYMU President Ovid J. L. Tzeng, upon becoming Minister of Education (MOE) in 2000, quickly facilitated a consensus among the three university presidents. A federated “university system,” modeled after the University of California, was proposed.

This system would include a joint headquarters and a new campus in Hsinchu, co-developed with the National Health Research Institutes while maintaining each university's existing campuses.After years of discussions among the three universities, NCTU moved ahead with a merger independently with NYMU, while NTHU turned its focus to establishing a medical school in partnership with Mackay Memorial Hospital. In March 2001, the merger was ultimately shelved due to insufficient support from NCTU's University Affairs Meeting.

Although the merger discussions around 2000 did not come to fruition, they planted the seeds for future integration. In 2015, several universities—including NTHU, NCTU, and National Chengchi University (NCCU)—renewed their interest in deepening collaboration and exploring merger possibilities with then-NYMU President Liang Kung-Yee. Considering the history of past discussions and the institutions' complementary strengths, Liang prioritized resuming talks with NCTU.Although the merger appeared imminent, inadequate communication left many faculty and students unaware of its background, ultimately causing the merger to fail.