Natitingou [na.ti.tɛ̃ŋ.gu], informally referred to as Nati [na.ti], is a city and commune in north western Benin and the capital of Atakora Department. The commune covers an area of 3045 square kilometres and as of 2013 had a population of 104,010 people.

Natitingou, like many areas of Benin, is home to a constituent monarchy.

The town was founded by the Waama ethnic groups but is populated with Ditammari, Dendi, Nateni, Fulani, Fon, and many other ethnic groups. According to popular etymology, the town takes its name from the word Nantibatingou, from the Waama root "Nanto" meaning to crush, as the local people were renowned growers of sorghum which was native to the area and later millet.

Natitingou is evenly divided between Christians and Muslims and, like the rest of Benin, is notable for its ethnic and religious tolerance.

The mountains surrounding the region to the east and west sides are important in local animists, who believe them to be inhabited by spirits. Certain people subscribe to the idea that during the evening these spirits emit sounds similar to those produced by stones which women uses to crush cereal grains. Adherents do not crush cereals in the evening, so as not to confuse the two sounds.

European missionaries visited Natitingou in the 19th century and early 20th century.

The town of Natitingou belongs to the Department of Atakora in northwestern Benin. It lies in a semi-valley, formed by the two mountain ridges that surround it. Natitingou is located 645 km from the economic capital of Cotonou and 100 km from Porga at the entrance of the Pendjari National Park. The commune is bounded on the north by Toucountouna, south and east by Kouandé and to the west by the commune of Boukombé.

The climate in Natitingou is drier than in the south, particularly during the Harmattan season in December/January, when humidity can be as low as 10% and night temperatures can be as low as 17 degrees Celsius.