The genus Neacomys, also known as bristly mice because of their spiny fur, includes several species of rodents in the tribe Oryzomyini of family Cricetidae. It is most closely related to Oligoryzomys, Oreoryzomys, and Microryzomys. Neacomys species are mainly found in the Amazon basin, but N. pictus occurs in Panama and N. tenuipes in montane Colombia.

There are currently about 24 described species in the genus.