Neoschizomer

Neoschizomers are restriction enzymes that recognize the same nucleotide sequence, but cleave at different sites. The first restriction enzyme discovered to recognize a sequence is called the prototype, and others that recognize the same sequence are isoschizomers. Neoschizomers are a subset of isoschizomers.^[1]

For example, MaeII is the prototype enzyme for the sequence "ACGT", with the cleavage site A↓CGT. One of its neoschizomers, Tsp49I, also recognizes the sequence "ACGT", but cleaves at ACGT↓.^[2]

Another example is SmaI (CCC↓GGG), which is a neoschizomer of XmaI (C↓CCGGG).^[3]

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Wikidata has the property:

• neoschizomer (P4875) (see uses)

• Isoschizomer
• Isocaudomer
• List of restriction enzyme cutting sites

1. ^ "Isoschizomers". New England Biolabs. Retrieved 2024-09-12.
2. ^ Welch, S. (1996-05-15). "Tsp49I (ACGT↓), a Thermostable Neoschizomer of the Type II Restriction Endonuclease Mae II (A↓CGT), Discovered in Isolates of the Genus Thermus from the Azores, Iceland and New Zealand". Nucleic Acids Research. 24 (10): 1799–1801. doi:10.1093/nar/24.10.1799. PMC 145888. PMID 8657557.
3. ^ Withers, Barbara E.; Dunbar, Joan C. (1995). "DNA determinants in sequence-specific recognition by Xm al endonuclease". Nucleic Acids Research. 23 (17): 3571–3577. doi:10.1093/nar/23.17.3571. PMC 307239. PMID 7567471.

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