Neuquén (Spanish pronunciation: [newˈken]; Mapudungun: Nehuenken) is the capital city of the Argentine province of Neuquén and of the Confluencia Department within that province, located in the extreme east of the province. It occupies a strip of land west of the confluence of the Limay and Neuquén rivers which form the Río Negro, making it part of the ecoregion of Alto Valle del Río Negro. The city had 287,787 inhabitants, and the surrounding Neuquén – Plottier – Cipolletti conurbation had a population of more than 500,000 at the 2022 Census, making it the largest urban agglomeration in Patagonia.

Founded in 1904, it is the newest provincial capital city in Argentina.

The name of the city comes from the Neuquén River, which in Mapuche language means 'water that has strength'. This name was already used since 1884 for the federal territory. Since 1902, it was used for the railway station of the town, which at that time was a hamlet called Confluencia. The name of the town was officially chosen in 1904, when it was declared the capital of the territory. It is the only Argentine city that has a palindrome name, that is a word which reads the same backward as forward.

Neuquén is both an important agricultural center, surrounded by fertile lands irrigated by the waters of the Limay and Neuquén rivers in an otherwise arid province, and a petrochemical industrial center that receives oil extracted from different points of the province. It belongs economically and geographically to the Alto Valle region that produces apples, pears, and other fruits.

With the discovery of the Vaca Muerta oil fields west of the city (the third largest shale gas and oil reserves in the world),^{[citation needed]} it has begun to experience a boom in real estate and construction. It is expected that over the next few years the city will experience unprecedented growth as it is the only significant city in the region. It has an airport, shopping centers, office space and institutions to become the center of the operations not only of the oil and gas companies, but also their suppliers.

National Route 22 (RN22) is the main road linking Neuquén with the rest of Argentina. Since 2021 it runs in eastern-western direction north of the city center through the Parque Industrial area, mostly as a four-lane motorway, linking the city with the Atlantic coast at Bahía Blanca to the East and Temuco (Chile), San Carlos de Bariloche and Zapala to the West and South-West. The former RN22, now called Avenida General Mosconi, a wide fast-transit avenue, runs in east-western direction through the southern part of the city center and divides the city into two halves.

The Presidente Perón Airport is 8 kilometres (5 miles) west of the city center near the boundary to Plottier and serves regular flights to Buenos Aires, Córdoba, Salta, Mendoza, Comodoro Rivadavia and San Martín de los Andes.

The Tren del Valle commuter rail service links Neuquén with neighbouring Cipolletti and Plottier. Freight trains run to Bahía Blanca and Zapala.