The New Guangxi clique (Chinese: 新桂系; pinyin: Xīn Guìxì), led by Li Zongren, Huang Shaohong, and Bai Chongxi, was a warlord clique during the Republic of China. After the founding of the Republic, Guangxi served as the base for the Old Guangxi clique, one of the most powerful warlord cliques of China. In the early 1920s, the Guangdong–Guangxi War saw the pro-Kuomintang New Guangxi clique replace the Old clique.

In 1920, Chen Jiongming drove Lu Rongting and the Old Guangxi clique out of Guangdong in the First Yue-Gui War. In 1921, Chen pushed into Guangxi, starting the Second Yue-Gui War, forcing Lu to step down in July 1921. By August, Chen had occupied Nanning and the rest of Guangxi, and continued to do so until April 1922. Their occupation was largely nominal because armed bands of Guangxi loyalists began to gather under local commanders, calling themselves the Self-Government Army. Sun Yat-sen and Chen soon split over the continuation of the Northern Expedition. Chen, however, aspired merely to be the warlord of Guangdong and after the Zhili Clique in Beijing recognized his power in the south, he abandoned Sun. By May 1922, the Cantonese forces had evacuated Guangxi leaving a power vacuum.

Lu Rongting could construct a political and military machine from the forces that composed the Self-Government Armies, by calling on friends, family, and members of the Zhuang ethnicity, but the lack of such a leader led to a rapid collapse into localism, which occurred as the Guangdong forces withdrew. There was intense fighting to re-occupy territory or to attempt to strip the retreating forces of their supplies and munitions.

With the support of Wu Peifu and the Zhili Clique, Lu slipped back into Guangxi in 1923 and began to try to rebuild his coalition. He soon had control over the south with its important pool of Zhuang manpower, but the situation had changed and his political organization could not be rebuilt. Among the younger men who had been trained in military schools after the 1911 Revolution, there was a new appreciation for modern tactics, weapons, and political means. In the confused power struggles following the Yue-Gui Wars, these local military men began to carve out territory in Guangxi and dominate it.

In the southwest there were opium trails from Yunnan and Guizhou that ran through Baise and then down the river to Nanning. From there, opium usually went out through Wuzhou, where the trade was financed. During the Yue-Gui wars, Huang Shaohong, then the commander of the Model Battalion of the 1st Guangxi Division, and Bai Chongxi, his former deputy, attempted to stay neutral and relocated to Baise. Huang eventually got control of Baise, and the opium trade. Later he expanded his control to Wuzhou, thus controlling the routes through which opium both entered and left Guangxi. With his opium revenue Bai was able to build a well-equipped and trained force.

During the Yue-Gui Wars, Li Zongren had accompanied Lu and Lin Hu into Guangdong and led the rear guard when the Old Guangxi Clique forces retreated before Chen Jiongming's attack. During the campaign, Li's battalion was reduced to about one thousand men and "sank into the grasses." But Li, intending to become more than a bandit, began building a personal military machine of professional units of soldiers. These were to be the equal of any force in China and more than a match for any number of bandits or Zhuang irregulars that Lu drew on in his war to re-establish his power in Guangxi. Li joined the Kuomintang in 1923, when he already controlled a considerable numbers of troops in northern Guangxi and wiped out the local bandits, warlords, and remnant forces of the Old Guangxi clique in the north.

By the spring of 1924, Huang Shaohong, Bai Chongxi, and Li Zongren, formed the New Guangxi clique and had created the well equipped Guangxi Pacification Army. Li was the Commander in Chief, Huang the deputy Commander, and Bai the Chief-of-Staff. By August they had defeated and driven the former ruler Lu Rongting and other contenders out of the province. Li was military governor of Guangxi from 1924–25, and from 1925 to 1949.

The coalition's efforts brought Guangxi under the jurisdiction of the Republic of China. Li was the military governor of Guangxi from 1924–25, Huang became the civil governor of Guangxi from 1924 to 1929, and Guangxi remained under Li's influence until 1949. The New Guangxi clique made attempts at modernising between 1926 and 1927, when the Guangxi clique controlled Guangxi and much of Guangdong, Hunan, and Hubei. The New Guangxi clique was much more active in modernizing than Lu Rongting had been. They founded the University of Guangxi in Nanning, built over five thousand kilometers of roads and extended electrification of the area. Li also authorized the funding of middle class farmers to produce at full capacity, exporting additional rice to neighboring Guangdong province. Guangxi also retained lots of heavy industry in major urban centers, but in many cases lacked the expertise or workers to operate it, only operating around 96 factories for the entire province. Guangxi was also spared from any rampant corruption unlike the rest of China, also retaining a very stable economy.