New York State Route 80

New York State Route 80 (NY 80) is a 127.32-mile-long (204.90 km) west–east New York State Route located within Onondaga, Madison, Chenango, Otsego, Herkimer, and Montgomery counties in New York. Its western terminus is located at a junction with NY 175 in the city of Syracuse in Onondaga County, from which it actually runs in a north–south direction for 20 miles (32 km). The eastern terminus is located at a junction with NY 5 in the village of Nelliston in Montgomery County. The route is signed north–south from U.S. Route 20 (US 20) north to NY 5.

Most of NY 80 between Sherburne and Cooperstown follows the routing of the Second Great Western Turnpike, a 19th-century toll road.

Although NY 80 follows an east–west alignment for most of its routing, two sections, located on its western and easternmost ends, are either signed as north–south (as is the case in northern Otsego County and Montgomery County) or physically oriented from north to south (such as in central Onondaga County).

NY 80 begins at an intersection with NY 175 in southern Syracuse. The route, named Valley Drive, proceeds south through a largely residential area of Syracuse, following the path of Onondaga Creek through the area. 1 mile (1.6 km) to the south of NY 175 (and 1 mile (1.6 km) west of the interchange between Interstate 81 and Interstate 481), NY 80 intersects NY 173 (the old path of the Seneca Turnpike) near the southern city limits, which erroneously shows it as NY 80's western terminus in the 2017 route log. Past NY 173, NY 80 parallels U.S. Route 11, I-81, and Onondaga Creek as all four head south out of Syracuse. At the city line, NY 80 becomes South Onondaga Road.

In Onondaga, south of Syracuse, NY 80 briefly enters the Onondaga Nation Territory, cutting across the northwestern corner of the reservation before turning to follow the western edge of the territory. NY 80 leaves to the southwest shortly after to serve South Onondaga and intersect U.S. Route 20 at Lords Corners. Past US 20, NY 80 continues south to Otisco (coming within 3 miles (5 km) of Otisco Lake), then curves southeast to the Tully hamlet of Vesper before turning fully to the east as it enters the village of Tully.

Just west of Tully, NY 80 intersects NY 11A, US 11, and NY 281 on opposite sides of an overpass carrying I-81 over NY 80. Here, all three routes, plus County Route 134 (CR 134) to the southwest, act as frontage roads for I-81 exit 14. US 11 joins NY 80 east of the interchange, following the route into Tully. US 11 heads south at the village center; NY 80, however, continues eastward, overlapping NY 91 near Fabius and NY 13 in western Madison County. Past NY 13, NY 80 continues southeast to Georgetown, where it meets NY 26. The two routes conjoin and head south into Chenango County before separating shortly after crossing the county line. Within Chenango County, NY 80 largely follows an east–west routing with a slight curve to the southeast. Incorporated municipalities 80 passes through within Chenango County include Smyrna, Sherburne, and New Berlin. East of Smyrna, NY 80 continues east, then curves to the southeast as it approaches the Otsego County line, delimited by the Unadilla River.

After crossing over the Chenango River and into Sherburne, NY 80 intersects NY 12 and begins to follow the old path of the Second Great Western Turnpike across Central New York. The route continues east to Columbus, where NY 80 separates from the old routing of the turnpike, at an intersection with CR 25. From Columbus NY 80 heads southeast to intersect NY 8 north of New Berlin. NY 80 turns south onto NY 8, overlapping the route to New Berlin, where the routes split at the village center. Outside of New Berlin, NY 80 heads northeast to Edmeston, where it rejoins the routing of the Second Great Western Turnpike at an intersection with CR 20. From Edmeston NY 80 heads east to intersect NY 51 in West Burlington, creating a brief, 1-mile (1.6 km) long concurrency between the two routes. Soon after NY 51 splits off NY 80 and continues north toward West Winfield.

NY 80 heads due east from NY 51 to Otsego, where it meets NY 205. NY 205 joins NY 80 eastward into a small valley surrounding Oaks Creek, where the two routes meet NY 28. While NY 205 terminates here, NY 80 joins NY 28, following the route east across the creek and through the hamlet of Fly Creek.