A nicotini refers to any alcoholic drink that includes nicotine as an ingredient. Nicotinis are often made by infusing vodka with tobacco leaves, which is said to give the resulting beverage a 'smoky' flavor.

Its name is modeled after the word "martini" in the fashion of such drinks as the appletini.

In places which ban smoking, use of the nicotini provides smokers with the opportunity to manage cravings without stepping outside to smoke. Where nicotinis are not sold, a similar experience can be had by consuming a nicotine replacement therapy product such as nicotine chewing gum, followed by the consumption of an alcoholic beverage.

Nicotine replacement therapy products may be used to add a verified quantity of nicotine to produce a nicotini. The New York Times Magazine reported that one variation of the nicotina includes Kahlúa, a coffee-flavored liquor.

Tobacco and nicotine use increase alcohol craving. Nicotine poisoning may occur from homemade tobacco infused drinks due to varying quantity of nicotine.^{[citation needed]}