Notre-Dame-de-Grâce (French: [nɔtʁə dam də ɡʁɑs], locally [nɔtʁ̥œ̈ dam dœ̈ ɡʁɑːs], lit. 'Our Lady of Grace'), commonly known as NDG, is a residential neighbourhood of Montreal in the city's West End, with a population of 68,152 (2021). An independent municipality until annexed by the City of Montreal in 1910, NDG is today one half of the borough of Côte-des-Neiges–Notre-Dame-de-Grâce. It comprises two wards, Loyola to the west and Notre-Dame-de-Grâce to the east. NDG is bordered by four independent enclaves; its eastern border is shared with the City of Westmount, Quebec, to the north and west it is bordered by the cities of Montreal West, Hampstead and Côte-Saint-Luc. NDG plays a pivotal role in serving as the commercial and cultural hub for Montreal's predominantly English-speaking West End, with Sherbrooke Street West running the length of the community as the main commercial artery. The community is roughly bounded by Claremont Avenue to the east, Côte-Saint-Luc Road to the north, Brock Avenue in the west, and Highway 20 and the Saint-Jacques Escarpment to the south.

At the time of Montreal's founding in 1642 most of the land stretching past Mount Royal to the northwest was a vast forest running the length of a long, narrow ridge known as the Saint Jacques Escarpment. The area that was to become Notre-Dame-de-Grâce was founded along that ridge, near a since-drained Lac Saint-Pierre. The first Europeans settled the area eight years after the founding of the colony of Ville Marie, on November 18, 1650. They were Jean Descarries (or Descaris) dit le Houx and Jean Leduc, from Igé, Perche, France.

Both settlers received 30 acres (12 ha) of land in Notre-Dame-de-Grâce, a vast territory that stretched from what would become Atwater Avenue to Lachine. The eastern part of the territory split off in 1874 as the village of Côte-Saint-Antoine, later renamed Westmount; a section then split off the western edge in 1897 to become Montreal West.

In 1853, construction of the Church of Notre-Dame-de-Grâce was completed.

In December 1876, the Municipality of the Village of Notre-Dame-de-Grâce was established through proclamation. In 1906, the village of Notre-Dame-de-Grâce was incorporated as a town. On June 4, 1910, Notre-Dame-de-Grâce was annexed to the city of Montreal.

It was during this period that the long-established Descarries family reached its peak. Daniel-Jérémie Décarie (1836-1904) was mayor of Notre-Dame-de-Grâce from 1877 to 1904 and his son, lawyer Jérémie-Louis Décarie (1870-1927), was a Quebec parliamentarian.

In May 1912, Décarie Boulevard was officially designated, running north–south from Côte-des-Neiges and the Town of Mount Royal in the north to Saint-Henri and Côte-Saint-Paul in the south (a section of the road was already known as Décarie Avenue).

In 1908, the first tramway made its appearance in Notre-Dame-de-Grâce, running around the north side of Mount Royal from Snowdon Station to the intersection of Mount Royal and Parc avenues.