The Nuova Famiglia (Italian: "New Family") was an Italian Camorra confederation created in the late 1970s and headed by the most powerful Camorra bosses of the time, Carmine Alfieri, the Nuvoletta brothers, Michele Zaza, Luigi Giuliano and Antonio Bardellino, to face Raffaele Cutolo's Nuova Camorra Organizzata, and affiliated with the Sicilian Mafia.

Originally called "Nuova Fratellanza Napolitana" (New Neapolitan Brotherhood), later rebaptized by the media as "Nuova Famiglia", was established in response to the expansion of Raffaele Cutolo's Nuova Camorra Organizzata (NCO) in Campania. The formation of the group was primarily led by Luigi Giuliano, who, despite his young age, possessed sufficient authority to organize opposition against Cutolo. Giuliano convened a meeting in a garage in the Forcella district, attended by approximately two hundred individuals, all committed to resisting NCO aggression. His decisive demeanor and persuasive arguments were instrumental in galvanizing even the most hesitant participants, thereby consolidating his position as the leader of the anti-Cutolo faction. Within weeks, Giuliano emerged as the head of the Nuova Fratellanza, establishing the organization as a direct competitor to the NCO.

Giuliano’s principal ally in this endeavor was Luigi Vollaro, known as "the Caliph", founder of the Vollaro clan from Portici, whose clandestine gambling operations provided financial and logistical support. Vollaro and the Giuliano clan formalized their alliance by creating a structured organization governed by its own statutes, aimed at countering Cutolo’s influence and preserving the autonomy of their illicit enterprises. Documentary evidence from trials against figures such as Mario Fabbrocino and members of the Giuliano clan attests to the violent confrontations between the Nuova Fratellanza and the NCO. These documents include correspondence from incarcerated affiliates, which frequently described ongoing hostilities and urged active participation in the conflict.

Beginning in 1980, additional families, including the Zaza clan, joined the original coalition. Initially neutral, the Zaza family eventually allied with the Nuova Fratellanza, influenced in part by their connections to the Sicilian Mafia, with which Cutolo had refused to establish ties. This expansion marked the consolidation of the Nuova Fratellanza as the main force against the Nuova Camorra Organizzata in Campania.

The confederation included:

The war that ensued between the Nuova Camorra Organizzata and the Nuova Famiglia caused a huge number of victims. This caused in turn a greater attention from the Italian police organizations, pushing Cosa Nostra to accommodate an agreement between the two warring clans, hopefully favouring the Nuova Famiglia, which included a lot of former allies.

In 1982, Alfieri and his ally, Pasquale Galasso decided to eliminate the senior NCO leaders, in revenge for the murder of his brothers during the war. In November 1982, the NCO's financier, Alfonso Ferrara Rosanova, was murdered. When his deputy and main 'military' chief, Vincenzo Casillo was killed via car bomb in January 1983 by Galasso, it was clear that Raffaele Cutolo had lost the war. His power declined considerably. Not only Cutolo but many other Camorra gangs understood the shift in the balance of power caused by the death of Casillo. They abandoned the NCO and allied themselves with Alfieri.

The elimination of the key NCO figures not only marked the end of the NCO's defeat as a political and criminal force, but also the rise of Carmine Alfieri and the NF who, by now, virtually unopposed, replaced them as the main contact of the politicians and businessmen in Campania as well as other criminal organizations. These chain of killings, including that of Cutolo's son, Roberto Cutolo who was shot dead by members of the Fabbrocino clan on 24 December 1990, aged 28, coupled with the incarceration of many of its members brought an end to the Nuova Camorra Organizzata.