NVM Express (NVMe) or Non-Volatile Memory Host Controller Interface Specification (NVMHCIS) is an open, logical-device interface specification for accessing a computer's non-volatile storage media usually attached via the PCI Express bus. The initial NVM stands for non-volatile memory, which is often NAND flash memory that comes in several physical form factors, including solid-state drives (SSDs), PCIe add-in cards, and M.2 cards, the successor to mSATA cards. NVM Express, as a logical-device interface, has been designed to capitalize on the low latency and internal parallelism of solid-state storage devices.

Architecturally, the logic for NVMe is physically stored within and executed by the NVMe controller chip that is physically co-located with the storage media, usually an SSD. Version changes for NVMe, e.g., 1.3 to 1.4, are incorporated within the storage media, and do not affect PCIe-compatible components such as motherboards and CPUs.

By its design, NVM Express allows host hardware and software to fully exploit the levels of parallelism possible in modern SSDs. As a result, NVM Express reduces I/O overhead and brings various performance improvements relative to previous logical-device interfaces, including multiple long command queues, and reduced latency. The previous interface protocols like AHCI were developed for use with far slower hard disk drives (HDD) where a very lengthy delay (relative to CPU operations) exists between a request and data transfer, where data speeds are much slower than RAM speeds, and where disk rotation and seek time give rise to further optimization requirements.

NVM Express devices are chiefly available in the miniature M.2 form factor, while standard-sized PCI Express expansion cards and 2.5-inch form-factor devices that provide a four-lane PCI Express interface through the U.2 connector (formerly known as SFF-8639) are also available.

Specifications for NVMe released to date include:

Historically, most SSDs used buses such as SATA, SAS, or Fibre Channel for interfacing with the rest of a computer system. Since SSDs became available in mass markets, SATA has become the most typical way for connecting SSDs in personal computers; however, SATA was designed primarily for interfacing with mechanical hard disk drives (HDDs), and it became increasingly inadequate for SSDs, which improved in speed over time. For example, within about five years of mass market mainstream adoption (2005–2010) many SSDs were already held back by the comparatively slow data rates available for hard drives—unlike hard disk drives, some SSDs are limited by the maximum throughput of SATA.

High-end SSDs had been made using the PCI Express bus before NVMe, but using non-standard specification interfaces, using a SAS to PCIe bridge or by emulating a hardware RAID controller. By standardizing the interface of SSDs, operating systems only need one common device driver to work with all SSDs adhering to the specification. It also means that each SSD manufacturer does not have to design specific interface drivers. This is similar to how USB mass storage devices are built to follow the USB mass-storage device class specification and work with all computers, with no per-device drivers needed.

NVM Express devices are also used as the building block of the burst buffer storage in many leading supercomputers, such as Fugaku Supercomputer, Summit Supercomputer and Sierra Supercomputer, etc.