OR5V1

OR5V1
Identifiers
Aliases	OR5V1, 6M1-21, hs6M1-21, olfactory receptor family 5 subfamily V member 1
External IDs	MGI: 2177493; HomoloGene: 73968; GeneCards: OR5V1; OMA:OR5V1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 29,353,749 bp[1] End 29,431,967 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 37,803,359 bp[2] End 37,811,098 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis right testis caudate nucleus hypothalamus Top expressed in olfactory bulb More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81696 258325 Ensembl ENSG00000112461 ENSG00000227137 ENSG00000243441 ENSG00000243729 ENSG00000233046 ENSG00000230742 ENSG00000240130 ENSG00000242289 ENSMUSG00000090894 UniProt Q9UGF6 A2RT31 RefSeq (mRNA) NM_030876 NM_146328 RefSeq (protein) NP_110503 NP_666440 Location (UCSC) Chr 6: 29.35 – 29.43 Mb Chr 17: 37.8 – 37.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 5V1 is a protein that in humans is encoded by the OR5V1 gene.^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[5]

Functional studies of the mouse ortholog (Olfr110) have identified this receptor as a high-affinity sensor for the oxylipin 12(S)-hydroxyeicosapentaenoic acid (12(S)-HEPE), revealing a role beyond classical odorant detection in regulating metabolism. Engagement of this receptor by oxylipins activates G_s-dependent signaling pathways that promote fatty acid oxidation and influence glucose homeostasis, indicating a potential role for OR5V1 in metabolic processes and as a therapeutic target for metabolic disorders.^[6]

• OR5V1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by adding missing information.

• v
• t
• e