Odem is a city in San Patricio County, Texas, United States. Its population was 2,255 at the 2020 census.

The city was platted in 1909 by John James Welder and David Odem. It was named for Odem, who was the county sheriff.

Odem is located at 27°56′52″N 97°35′3″W / 27.94778°N 97.58417°W / 27.94778; -97.58417 (27.947773, –97.584169).

According to the United States Census Bureau, the city has a total area of 1.1  sq mi (2.9 km²), all land.

As of the 2020 census, there were 2,255 people, 801 households, and 542 families residing in the city. The median age was 39.1 years. 24.9% of residents were under the age of 18 and 18.0% of residents were 65 years of age or older. For every 100 females there were 91.6 males, and for every 100 females age 18 and over there were 90.0 males age 18 and over.

0.0% of residents lived in urban areas, while 100.0% lived in rural areas.

There were 801 households in Odem, of which 37.8% had children under the age of 18 living in them. Of all households, 46.1% were married-couple households, 17.2% were households with a male householder and no spouse or partner present, and 30.1% were households with a female householder and no spouse or partner present. About 22.6% of all households were made up of individuals and 10.6% had someone living alone who was 65 years of age or older.

There were 901 housing units, of which 11.1% were vacant. The homeowner vacancy rate was 1.7% and the rental vacancy rate was 8.0%.