Omega Upsilon Phi (ΩΥΦ) was a professional medical fraternity founded at the University at Buffalo in 1894. It merged with Phi Beta Pi in 1934.

Omega Upsilon Phi was founded at the University at Buffalo in Buffalo, New York on November 15, 1894 as a professional fraternity for medical students. Its founders were:

Its publication was Omega Upsilon Phi Quarterly; it was first published in 1901. The fraternity was a member of the Professional Fraternity Association.

Omega Upsilon Phi went defunct in 1934 after merging with Phi Beta Pi medical fraternity.

Omega Upsilon Phi's badge was a shield with a monogram of the Greek letters ΩΥΦ below an eye. Its colors were crimson and gold. The fraternity's flower was the red carnation.

Omega Upsilon Phi had four degrees in its ritualistic work; three secret undergraduate degrees and one open honorary degree known as the Hippocratic Degree. The latter was conferred by the grand chapter.

Omega Upsilon Phi was governed through an annual conference called the Grand Chapter. The grand chapter consisted of three representatives from each chapter and the officers and past officers of the grand chapter.

Omega Upsilon Phi chartered 26 chapters. Inactive chapters and institutions are indicated in italics.