Osco Drug and Sav-on Drugs were the names of a pair of chain pharmacies that operated in the United States. Osco Drug was founded by the Skaggs family. The grocery store chain Alpha Beta was purchased by American Stores in 1961. Skaggs Drug Centers bought American Stores in 1979 and assumed the American Stores name. Sav-on Drugs was a California-based pharmacy chain that was acquired by Osco's parent company in 1980. Both Osco and Sav-on stores eventually came under the ownership of American Stores, then Albertsons, and finally SuperValu before the stores were sold off.

The Osco and Sav-on brands survive today as brandings for in-store pharmacies in the Albertsons chain of stores. Osco pharmacies can be found in Jewel stores, which are co-branded Jewel-Osco, as well as in Shaw's and Star Markets. Sav-on pharmacies are found largely in Acme stores. Pharmacies in Albertsons stores are called Osco in Arizona and Montana stores, and Sav-On in other markets, in Nevada and predominantly in Texas for example.

In 1915, S.M. Skaggs, a Baptist minister, opened a grocery store in American Falls, Idaho, with lower prices on goods. In 1917, O.P Skaggs started a chain of self-service stores, and later sold the franchise in the western states to Christian Call. In 1926, the Skaggs brothers merged the chain with Sam Seelig stores, which had become Safeway in 1925. L.J. Skaggs retired from Safeway in 1932, and in 1934, he opened the first self-service drugstore in the US in Tacoma, Washington.

Loronzo L. (L.L.) Skaggs owned a controlling stock in a company called Quality Food in Minnesota and subsequently left the Safeway business. L.L. opened a chain of self-service drugstores in the Midwest similar to his brother L.J.'s stores in the west. The first store opened in 1937 in Rochester, Minnesota, and was named "Pay-Less" (different from the drug chain Payless founded later in the century), and was managed by George Hilden. The store remained in operation until 1987, when it closed due to redevelopment in downtown Rochester.

In 1937, while in the process of opening a second store in Mason City, Iowa, it was learned that another company had already registered the name "Payless" in the state. L.L changed "Payless" to "Self-Service Drug, Inc." and formed a new corporation.

In 1942, the corporation "Self-Service Drug, Inc." was dissolved and succeeded by "Owners Service Company", a partnership of L.L Skaggs, H.B. Finch, Paul Stratton and George Hilden. From this company 'Osco' was coined. That year Osco moved its headquarters from Waterloo, Iowa, to the Merchandise Mart in Chicago, Illinois.

Sav-on Drugs was a Southern California-based drugstore chain that was founded by Christian J. Call in San Bernardino, in July 1945. Ira D. Brown served as general manager. The chain was the second largest California-based drugstore chain in Southern California at the time it was acquired by The Jewel Companies in November 1980.

In October 1947, the third store in the chain opened in Long Beach. The store was managed by Ronald L. Call while the chain was co-owned at that time by Christian J. Call and Alton D. Clark