Oscorp (sometimes stylized as OsCorp), also known as Oscorp Industries, is a fictional multibillion-dollar multinational corporation appearing in American comic books published by Marvel Comics, predominantly in stories about Spider-Man. The company was founded by Norman Osborn and has appeared in numerous media adaptations. It first appeared in The Amazing Spider-Man #37 (March, 1966) and was created by Stan Lee and Steve Ditko.

The corporation is based out of the Oscorp Tower in New York. It was created and run by its CEO Norman Osborn. Norman studied chemistry and electrical engineering in college. He also took a number of courses in business administration. Norman's teacher, Professor Mendel Stromm, formed the business partnership. Since Norman put up the bulk of the financing, they called their company the Osborn Corporation, or Oscorp.

Stromm's early research was on a chemical that would provide enhanced strength in its test subjects and would eventually turn Osborn into the Green Goblin. Osborn, wanting the formula for himself, discovered that Stromm had been embezzling funds from Oscorp. Stromm explained that he was merely borrowing but Osborn turned him over to the police. After several years in prison, Stromm was released and tried to kill Osborn for revenge using evil robots. He was stopped by the superhero Spider-Man and seemingly died of a heart attack when he was nearly shot.

Jay Allan's company "Allan Chemical" was merged with Normie Osborn's stocks from Oscorp and the last remaining properties of Horizon Labs after its destruction, establishing it under the new name of "Alchemax".

It was later revealed that Norman Osborn under the guise of "Mason Banks" created the corporation in order to leave a strong empire for his grandson and establish an empire for the Osborn legacy. Their headquarters Oscorp Tower was the former headquarters of Oscorp.

By 2099, Alchemax would eventually control most aspects of daily life in a possible future.

In the Ultimate Marvel universe, Oscorp is much the same as in the Earth-616 version. The company is owned and operated by Norman Osborn who developed the Oz super soldier serum and the spiders who were behind the abilities of Peter Parker, and later Miles Morales. After an incident in which Osborn injected himself with Oz serum and became the Green Goblin, a big portion of the main building was left in ruins, and numerous scientists died or transitioned to other companies like Roxxon in the case of Conrad Marcus. Osborn Industries had been mentioned to still produce technologies.

In Earth-6160, a world whose history was altered by the Maker, Oscorp is one of the largest companies of the North American Union, a regional power bloc which includes the former United States's territories after its central government dissolved in 1969. Norman Osborn operated as CEO before his death in a false flag attack on Stark Tower orchestrated by the Maker's Council. After his death Harry Osborn and Gwen Stacy become the two members of its board while the company's control passes to them and their trust as the sole inheritors. As Stark/Stane's assets become a matter of question and political intrigue due to the fall of the Starks, Wilson Fisk, the new Shadow Governor of the New York territory and Kingpin of Manhattan, appoints Harry to help take care of them during a meeting. Two weeks later, with the assistance of Otto Octavius, the Osborns covertly raid a hidden Stark location containing Iron Man armors, as well as a valuable data repository of files of information regarding suit designs, financial accounts, and the Council's operations. Utilizing Stark technology, Octavius creates the Green Goblin suit as Harry decides to fight against the Kingpin and the Council's reign over New York and the rest of the world, in order to avenge his father's death.