PCDH1

PCDH1
Identifiers
Aliases	PCDH1, PC42, PCDH42, protocadherin 1
External IDs	OMIM: 603626; MGI: 104692; HomoloGene: 12613; GeneCards: PCDH1; OMA:PCDH1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	141,879,246 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	38,345,106 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; beta cell; ; mucosa of transverse colon; ; right lung; ; minor salivary glands; ; skin of arm; ; apex of heart; ; upper lobe of left lung; ; skin of leg; ; olfactory zone of nasal mucosa;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; esophagus; ; lip; ; primary visual cortex; ; yolk sac; ; genital tubercle; ; tail of embryo; ; intestinal villus; ; epithelium of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; cell-cell junction; nucleus; nucleolus; cell junction; intracellular membrane-bounded organelle;
Biological process	cell-cell signaling; cell adhesion; nervous system development; homophilic cell adhesion via plasma membrane adhesion molecules;
	Sources:Amigo / QuickGO
Orthologs
	5097
	75599
	ENSG00000156453
	ENSMUSG00000051375
	Q08174
	n/a
	NM_001278613; NM_001278615; NM_002587; NM_032420
	NM_029357
	NP_001265542; NP_001265544; NP_002578; NP_115796
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin-1 is a protein that in humans is encoded by the PCDH1 gene.^[5]^[6]

This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracellular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156453 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051375 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sano K, Tanihara H, Heimark RL, Obata S, Davidson M, St John T, Taketani S, Suzuki S (Jul 1993). "Protocadherins: a large family of cadherin-related molecules in central nervous system". EMBO J. 12 (6): 2249–56. doi:10.1002/j.1460-2075.1993.tb05878.x. PMC 413453. PMID 8508762.
^ ^a ^b "Entrez Gene: PCDH1 protocadherin 1".

Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752. S2CID 44844497.
Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Del Mastro RG, Wang L, Simmons AD, et al. (1997). "Human chromosome-specific cDNA libraries: new tools for gene identification and genome annotation". Genome Res. 5 (2): 185–94. doi:10.1101/gr.5.2.185. PMID 9132272.
Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747. S2CID 18659460.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156453 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051375 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8508762-5] Sano K, Tanihara H, Heimark RL, Obata S, Davidson M, St John T, Taketani S, Suzuki S (Jul 1993). "Protocadherins: a large family of cadherin-related molecules in central nervous system". EMBO J. 12 (6): 2249–56. doi:10.1002/j.1460-2075.1993.tb05878.x. PMC 413453. PMID 8508762.

[entrez-6] "Entrez Gene: PCDH1 protocadherin 1".

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PCDH1

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