PIK3CG

PIK3CG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E8Y, 1E8Z, 1HE8, 2A4Z, 2A5U, 2CHW, 2CHX, 2CHZ, 2V4L, 3APC, 3APD, 3APF, 3CSF, 3CST, 3DBS, 3ENE, 3IBE, 3L08, 3L13, 3L16, 3L17, 3L54, 3LJ3, 3MJW, 3ML8, 3ML9, 3NZS, 3NZU, 3OAW, 3P2B, 3PRE, 3PRZ, 3PS6, 3QAQ, 3QAR, 3QJZ, 3QK0, 3R7Q, 3R7R, 3S2A, 3SD5, 3T8M, 3TJP, 3TL5, 3ZVV, 3ZW3, 4ANU, 4ANV, 4ANW, 4ANX, 4AOF, 4DK5, 4EZJ, 4EZK, 4EZL, 4F1S, 4FA6, 4FAD, 4FHJ, 4FHK, 4FJY, 4FJZ, 4FLH, 4FUL, 4G11, 4GB9, 4HLE, 4HVB, 4J6I, 4KZ0, 4KZC, 4PS3, 4PS7, 4PS8, 4URK, 4WWN, 4WWO, 4WWP, 4XX5, 4XZ4, 5EDS, 5G2N
Identifiers
Aliases	PIK3CG, PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma, IMD97
External IDs	OMIM: 601232; MGI: 1353576; HomoloGene: 68269; GeneCards: PIK3CG; OMA:PIK3CG - orthologs
EC number	2.7.11.1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	106,908,980 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	32,258,658 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; trabecular bone; ; bone marrow cell; ; blood; ; monocyte; ; epithelium of nasopharynx; ; granulocyte; ; lymph node; ; testicle; ; visceral pleura;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; blood; ; thymus; ; lumbar subsegment of spinal cord; ; bone marrow; ; spleen; ; stroma of bone marrow; ; lymph node; ; mesenteric lymph nodes;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; ephrin receptor binding; 1-phosphatidylinositol-4-phosphate 3-kinase activity; protein serine/threonine kinase activity; protein binding; phosphatidylinositol 3-kinase activity; ATP binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; kinase activity; 1-phosphatidylinositol-3-kinase activity; identical protein binding; phosphatidylinositol-3,4-bisphosphate 5-kinase activity;
Cellular component	cytoplasm; phosphatidylinositol 3-kinase complex; membrane; phosphatidylinositol 3-kinase complex, class IB; cytosol; mast cell granule; plasma membrane;
Biological process	regulation of protein phosphorylation; G protein-coupled receptor signaling pathway; positive regulation of protein kinase B signaling; regulation of cell adhesion mediated by integrin; endocytosis; adaptive immune response; respiratory burst involved in defense response; positive regulation of MAP kinase activity; immune system process; positive regulation of cytosolic calcium ion concentration; T cell chemotaxis; cytokine production; positive regulation of catalytic activity; secretory granule localization; dendritic cell chemotaxis; neutrophil chemotaxis; platelet activation; T cell proliferation; chemotaxis; protein phosphorylation; phosphatidylinositol-3-phosphate biosynthetic process; phosphatidylinositol phosphate biosynthetic process; natural killer cell chemotaxis; angiogenesis; positive regulation of acute inflammatory response; phosphatidylinositol biosynthetic process; negative regulation of fibroblast apoptotic process; phosphatidylinositol 3-kinase signaling; negative regulation of triglyceride catabolic process; mast cell degranulation; inflammatory response; innate immune response; platelet aggregation; neutrophil extravasation; T cell activation; regulation of calcium ion transmembrane transport; cellular response to cAMP; hepatocyte apoptotic process; phosphatidylinositol-mediated signaling; negative regulation of cardiac muscle contraction; phosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; cell migration;
	Sources:Amigo / QuickGO
Orthologs
	5294
	30955
	ENSG00000105851
	ENSMUSG00000020573
	P48736
	Q9JHG7
	NM_001282426; NM_001282427; NM_002649
	NM_001146200; NM_001146201; NM_020272
	NP_001269355; NP_001269356; NP_002640
	NP_001139672; NP_001139673; NP_064668
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PIK3CG gene.

Function

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.^[5] More recently, this gene has been shown to be a critical myeloid-restricted vulnerability in Acute Myeloid Leukemia (AML). Its targeting, either by the small-molecule inhibitor IPI-549 or by a first-in-class proteolysis-targeting chimera (PROTAC) named ARM165, has been shown to reduce AML cell progression both in vitro and in vivo.^[6]^[7]