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PLRG1

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PLRG1

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PLRG1

PLRG1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4YVD

Identifiers

PLRG1, Cwc1, PRL1, PRP46, PRPF46, TANGO4, pleiotropic regulator 1

External IDs

OMIM: 605961; MGI: 1858197; HomoloGene: 2004; GeneCards: PLRG1; OMA:PLRG1 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q31.3	Start	154,535,005 bp^[1]
Band	4q31.3	End	154,550,400 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 E3	Start	82,962,829 bp^[2]
Band	3\|3 E3	End	82,979,662 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

Achilles tendon

islet of Langerhans

smooth muscle tissue

body of uterus

left lobe of thyroid gland

palpebral conjunctiva

right lobe of thyroid gland

rectum

right uterine tube

Top expressed in

primitive streak

primary oocyte

maxillary prominence

mandibular prominence

medial ganglionic eminence

endocardial cushion

somite

abdominal wall

epiblast

superior cervical ganglion

More reference expression data

n/a

Gene ontology
Molecular function	protein binding
Cellular component	DNA replication factor A complex Cul4-RING E3 ubiquitin ligase complex catalytic step 2 spliceosome nuclear membrane spliceosomal complex precatalytic spliceosome Prp19 complex fibrillar center nucleoplasm nuclear speck U2-type catalytic step 2 spliceosome nucleus
Biological process	protein localization to nucleus positive regulation of G1/S transition of mitotic cell cycle mRNA processing RNA splicing mRNA splicing, via spliceosome
Sources:Amigo / QuickGO

Species

Human

Mouse


5356


53317


ENSG00000171566


ENSMUSG00000027998


O43660


Q922V4

RefSeq (mRNA)


NM_002669 NM_001201564


NM_016784

RefSeq (protein)


NP_001188493 NP_002660


NP_058064

Location (UCSC)

Chr 4: 154.54 – 154.55 Mb

Chr 3: 82.96 – 82.98 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Pleiotropic regulator 1 is a protein that in humans is encoded by the PLRG1 gene.^[5]

Interactions

PLRG1 has been shown to interact with CDC5L.^[6]^[7]^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171566 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027998 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PLRG1 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)".
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Ajuh P, Lamond AI (November 2003). "Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1". Nucleic Acids Res. 31 (21): 6104–16. doi:10.1093/nar/gkg817. PMC 275459. PMID 14576297.
^ Ajuh P, Sleeman J, Chusainow J, Lamond AI (November 2001). "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing". J. Biol. Chem. 276 (45): 42370–81. doi:10.1074/jbc.M105453200. ISSN 0021-9258. PMID 11544257.
^ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

Further reading

Németh K, Salchert K, Putnoky P, et al. (1998). "Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis". Genes Dev. 12 (19): 3059–73. doi:10.1101/gad.12.19.3059. PMC 317193. PMID 9765207.
Ajuh P, Kuster B, Panov K, et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
Ajuh P, Sleeman J, Chusainow J, Lamond AI (2001). "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing". J. Biol. Chem. 276 (45): 42370–81. doi:10.1074/jbc.M105453200. PMID 11544257.
Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC 186633. PMID 12176931.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ajuh P, Lamond AI (2003). "Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1". Nucleic Acids Res. 31 (21): 6104–16. doi:10.1093/nar/gkg817. PMC 275459. PMID 14576297.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Post-transcriptional modification

Precursor mRNA
5′ cap formation
Polyadenylation
- CPSF
- CstF
- PAP
- PAB2
- CFI
- CFII
Poly(A)-binding protein
RNA editing
Polyuridylation

Intron / Exon snRNP Spliceosome minor U1 Alternative splicing
pre-mRNA factors	PLRG1 PRPF3 PRPF4 PRPF4B PRPF6 PRPF8 PRPF18 PRPF19 PRPF31 PRPF38A PRPF38B PRPF39 PRPF40A PRPF40B

5′ cap methylation
mRNA decapping
- DCP1A
- DCP1B
- DCP2
- DCPS
- EDC3
- EDC4

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.