Pasquale Padalino (Italian pronunciation: [paˈskwaːle padaˈliːno]; born 26 July 1972) is an Italian football manager and a former central defender, currently in charge of Serie D club Città di Fasano.

During his career, Padalino represented Foggia, Bologna (two stints), Lecce, Fiorentina (where he formed an interesting defensive partnership with Lorenzo Amoruso, later of Rangers), Inter Milan (having only appeared once, in an Italian Cup contest against Udinese where he got injured on his right knee, after a contrast with Roberto Muzzi and missed out the rest of the season) and Como, where he ended his career in 2004.

Padalino's only international cap came in 1996, in a friendly against Bosnia-Herzegovina.

Having retired in 2004, Padalino started as assistant coach to cousin^{[citation needed]} Gian Piero Ventura at Hellas Verona, leaving at the end of the season to rejoin the first team at Foggia, as its administrative secretary.

In 2007–08, Padalino rejoined Ventura as his assistant at Pisa, also in the second level.

In 2009–10, Padalino started his career as head coach at Nocerina in the Seconda Divisione until the end of the season.

On 7 August 2012, he was named the new coach of Foggia in the Serie D. He led the team to promotion to Lega Pro in 2014 and then left the club.

In November 2014, he became the new manager of Grosseto in the Lega Pro, but he was fired in January 2015, before the end of the season.