Patience Lake is a lake in the central part of the Canadian province of Saskatchewan. The lake is east of Saskatoon in the Rural Municipality of Blucher No. 343. The lake serves as a groundwater discharge region for higher elevations to the east and west.

At the south end of the lake, Nutrien operates a solution mine that produces 331,000 tonnes of potash annually and has an approximately 50 ha (120-acre) region of the lake sectioned off with an earth dyke that is used to store brine tailings and saturated KCl solution. The potash mine was originally established as an underground mine, but due to flooding in 1988 it was converted to a solution mine.