Dybala made his professional debut with Instituto de Córdoba, scoring 17 goals in 38 appearances.

Dybala signed with Palermo, where he won a Serie B title and scored 21 goals in 89 appearances.

Dybala joined Juventus, where he won multiple Serie A titles and four Coppa Italia titles, scoring 82 goals in 210 appearances.

Dybala signed with Roma, where he has continued to excel, scoring 30 goals in 71 appearances.