Paulo Dybala was born in Laguna Larga, Córdoba, Argentina. His grandfather, Bolesław Dybała, was from Poland and fled to Argentina during World War II, contributing to Dybala's diverse heritage.

Dybala began his youth career at Instituto Atlético Central Córdoba, where he developed his skills and eventually made his professional debut in 2011.

Dybala made his professional debut in the Primera B Nacional (Argentine second division) with Instituto, scoring 17 goals in 38 matches and setting several records, including being the youngest to score a goal and the first to play 38 consecutive matches in a professional league in Argentina.

Dybala signed for Palermo in 2012, where he won a Serie B title and scored 21 goals in 89 appearances. His breakthrough season in 2014-15 saw him score 13 goals and provide 10 assists, attracting interest from top European clubs.

Dybala joined Juventus in 2015, where he won five Serie A titles and four Coppa Italia titles. He was named Serie A Most Valuable Player in the 2019-20 season and was included in the Serie A Team of the Year four times, becoming Juventus' ninth-highest all-time goalscorer with 115 goals in 293 appearances.

Dybala made his senior international debut for Argentina in 2015 at the age of 21 and has since earned over 40 caps, including appearances at the 2018 FIFA World Cup, 2019 Copa América, and 2022 FIFA World Cup, where Argentina won the title.

Dybala signed for Roma in 2022 on a three-year contract. He made his debut for the club in a 1-0 away win against Salernitana in Serie A and scored the first goal of the 2023 UEFA Europa League final, which Roma lost on penalties to Sevilla.

Dybala scored his first hat-trick for Roma in a 3-2 home win against Torino in Serie A and later scored his 50th goal for the club in a 2-1 home win against AC Milan in the 2023-24 UEFA Europa League quarter-finals.

Dybala's contract with Roma was extended until June 2026 after activating an extension clause, solidifying his role in the team.