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Peter Doherty (immunologist)
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Peter Doherty (immunologist)
Peter Charles Doherty (born 15 October 1940) is an Australian immunologist and Nobel laureate.
Doherty received the Albert Lasker Award for Basic Medical Research in 1995, the Nobel Prize in Physiology or Medicine jointly with Rolf M. Zinkernagel in 1996 and was named Australian of the Year in 1997. In the Australia Day Honours of 1997, he was named a Companion of the Order of Australia for his work with Zinkernagel. He is also a National Trust Australian Living Treasure.
In 2009 as part of the Q150 celebrations, Doherty's immune system research was announced as one of the Q150 Icons of Queensland for its role as an iconic "innovation and invention". In 2012, Doherty was appointed as an Honorary Professor in the School of Biochemistry and Immunology at Trinity College Dublin.
Peter Charles Doherty was born in the Brisbane suburb of Sherwood on 15 October 1940, to Eric Charles Doherty and Linda Doherty (née Byford). He grew up in Oxley, and attended Indooroopilly State High School (which now has a lecture theatre named after him).
After receiving his bachelor's degree in veterinary science in 1962 from the University of Queensland, he was a rural veterinary officer for the Queensland Department of Agriculture and Stock before taking up laboratory-based work at the Department's Animal Research Institute. There he met microbiology graduate Penelope Stephens and they were married in 1965. Doherty received his master's degree in veterinary science in 1966 from the University of Queensland.
He obtained his PhD in pathology in 1970 from the University of Edinburgh, Scotland, then returned to Australia to continue his research at the John Curtin School of Medical Research within the Australian National University in Canberra.
In 1988, Peter Doherty joined St. Jude Children's Research Hospital in Memphis, Tennessee as the Chair of the Department of Immunology, which he retained until 2001. Doherty's research focused on the immune system and his Nobel Prize-winning work described how the body's immune cells protect against viruses. He and Rolf Zinkernagel, the co-recipient of the 1996 Nobel Prize in Physiology or Medicine, discovered how T cells recognise their target antigens in combination with major histocompatibility complex (MHC) proteins.
Viruses infect host cells and reproduce inside them. Killer T-cells destroy those infected cells so that the viruses cannot reproduce. In landmark mouse studies of lymphocytic-choriomeningitis virus (LCMV), Rolf Zinkernagel and Doherty demonstrated that a T cell recognises an infected target only when it simultaneously detects (i) a viral peptide antigen and (ii) a self-specific molecule of the major histocompatibility complex class I (MHC I) displayed on the target-cell surface. This recognition was done by a T-cell receptor on the surface of the T cell.
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Peter Doherty (immunologist)
Peter Charles Doherty (born 15 October 1940) is an Australian immunologist and Nobel laureate.
Doherty received the Albert Lasker Award for Basic Medical Research in 1995, the Nobel Prize in Physiology or Medicine jointly with Rolf M. Zinkernagel in 1996 and was named Australian of the Year in 1997. In the Australia Day Honours of 1997, he was named a Companion of the Order of Australia for his work with Zinkernagel. He is also a National Trust Australian Living Treasure.
In 2009 as part of the Q150 celebrations, Doherty's immune system research was announced as one of the Q150 Icons of Queensland for its role as an iconic "innovation and invention". In 2012, Doherty was appointed as an Honorary Professor in the School of Biochemistry and Immunology at Trinity College Dublin.
Peter Charles Doherty was born in the Brisbane suburb of Sherwood on 15 October 1940, to Eric Charles Doherty and Linda Doherty (née Byford). He grew up in Oxley, and attended Indooroopilly State High School (which now has a lecture theatre named after him).
After receiving his bachelor's degree in veterinary science in 1962 from the University of Queensland, he was a rural veterinary officer for the Queensland Department of Agriculture and Stock before taking up laboratory-based work at the Department's Animal Research Institute. There he met microbiology graduate Penelope Stephens and they were married in 1965. Doherty received his master's degree in veterinary science in 1966 from the University of Queensland.
He obtained his PhD in pathology in 1970 from the University of Edinburgh, Scotland, then returned to Australia to continue his research at the John Curtin School of Medical Research within the Australian National University in Canberra.
In 1988, Peter Doherty joined St. Jude Children's Research Hospital in Memphis, Tennessee as the Chair of the Department of Immunology, which he retained until 2001. Doherty's research focused on the immune system and his Nobel Prize-winning work described how the body's immune cells protect against viruses. He and Rolf Zinkernagel, the co-recipient of the 1996 Nobel Prize in Physiology or Medicine, discovered how T cells recognise their target antigens in combination with major histocompatibility complex (MHC) proteins.
Viruses infect host cells and reproduce inside them. Killer T-cells destroy those infected cells so that the viruses cannot reproduce. In landmark mouse studies of lymphocytic-choriomeningitis virus (LCMV), Rolf Zinkernagel and Doherty demonstrated that a T cell recognises an infected target only when it simultaneously detects (i) a viral peptide antigen and (ii) a self-specific molecule of the major histocompatibility complex class I (MHC I) displayed on the target-cell surface. This recognition was done by a T-cell receptor on the surface of the T cell.
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