Physaria is a genus of flowering plants in the family Brassicaceae. Many species are known generally as twinpods, bladderpods, or lesquerella. They are native to the Americas, with many species endemic to western North America. They are densely hairy annual and perennial herbs often growing prostrate or decumbent, along the ground in patches or clumps. They bear inflorescences of bright yellow flowers. The fruit is often notched deeply, dividing into twin sections, giving the genus its common name.

Bladderpod oil is extracted from the seeds of Physaria fendleri and certain other species in the genus.

Due to the presence of both annual and perennial herbaceous members, this genus has been used as a model for allocation pattern comparisons between the annual and perennial life cycle.

Many of species of Physaria were formerly included in the now-defunct genus Lesquerella.

According to Plants of the World Online Species include: