Pickford is an unincorporated community in the U.S. state of Michigan. The community is centered along M-129 and is divided between Chippewa County to the east and Mackinac County.

As an unincorporated community, Pickford has no legally defined boundaries or population statistics of its own but does have its own post office with the 49774 ZIP Code.

Pickford was established in 1877 when Charles W. Pickford from Ontario first settled here along the Munuscong River. A post office was established in February 1880.

Pickford is located in the eastern Upper Peninsula of Michigan. Three quarters of the community is located within Chippewa County, while the southwestern quadrant of the community is located within Mackinac County. Pickford lies about 22 miles (35 km) south of Sault Ste. Marie.

Pickford is served by Pickford Public Schools. The district operates a public school within the community, with school teams known as the "Panthers".