Dead Space is a science fiction horror franchise created by Glen Schofield and owned by Electronic Arts. It was developed primarily by Visceral Games. The franchise's chronology is not presented in a linear format; each installment in the Dead Space franchise is a continuation or addition to a continuing storyline, with sections of the storyline presented in prequels or sequels, sometimes presented in other media from the originating video game series, which includes two films and several comic books and novels.

Primarily set in a 26th century science fiction universe featuring environments, weapons, and characters typical of the genre, the Dead Space franchise centers on a series of video games beginning with the release of the first Dead Space, which centers on starship engineer Isaac Clarke and mutated undead horrors that surround him. A central theme in the games is the fictional cult religion "Unitology" and its fanatical adherents, who believe that information about an alien artifact called the "Marker" is being suppressed by "EarthGov", the central political administration of Earth. Their primary goal is to use the Marker as a means to bring about the "Convergence", or complete destruction of humanity, with the Marker and its malevolent influence being the source of the undead monsters encountered by the series' protagonists.

The Dead Space video game series has been positively received; the first game in particular won a number of industry awards for the varied elements of its gameplay and development, and is often regarded as one of the best video games of all time by critics. From a commercial perspective, EA considered the video game series as a whole to have underperformed. After the financial disappointment of 2013's Dead Space 3, no further media for the franchise were produced until a remake of the first game was developed by Motive Studio and released on January 27, 2023.

Systems engineer Isaac Clarke joins a search and rescue team for the USG Ishimura, which had gone radio-silent, after receiving a message from his girlfriend Nicole. Their ship suffers damage when attempting to dock with the Ishimura; while the rest of the crew assess the situation and search for a means to leave the Ishimura, Isaac explores the ship to look for Nicole. The ship is overrun by Necromorphs, forcing Isaac to defend himself by weaponizing his mining tools and "Resource Integration Gear" (RIG) spacesuit capabilities. Due to the Red Marker's influence, Isaac experiences recurring visions of Nicole, who guides him to return the Marker to the planet. Towards the end of the game, it is revealed that one of the rescue team members, Kendra Daniels, is a double agent. She betrays Isaac, but is killed by a large Necromorph creature before she can escape, while Isaac commandeers her ship and escapes Aegis VII after defeating the creature and allowing the Marker to be destroyed by a sabotage attempt he had initiated earlier. The sole survivor of the entire ordeal, Isaac soon hears something behind him and looks back to see a horrific hallucination of Nicole.

Dead Space 2 reveals that Isaac has become mentally disturbed and unstable after he destroyed the Red Marker on Aegis VII, and that he was captured by EarthGov and taken to the Sprawl, a massive space-station built into the remains of Titan, Saturn's largest moon. Once there, EarthGov scientists extract information from his mind to build another Marker, and he is later confined to a hospital on the Sprawl due to a dementia-like mental illness caused by the first Marker. A Necromorph outbreak in the Sprawl instigated by the Marker copy soon occurs, thrusting Isaac into a struggle to survive the Necromorph epidemic. Haunted by hallucinations of the deceased Nicole Brennan, Isaac manages to destroy the Marker copy and undo its influence on his mind. Isaac succeeds in escaping with another survivor, Ellie Langford, before the explosive destruction of the station, and goes into hiding from EarthGov authorities as his mind still retains information about the Markers.

Dead Space 3 occurs a few years later. While Isaac Clarke and Ellie Langford returned to Earth and dated for a while, their relationship fell apart. As he is struggling with the breakup in his apartment on the moon, Unitologists led by Jacob Danik activate a Marker near the colony, causing a Necromorph outbreak. Isaac is rescued and enlisted by EarthGov soldiers to help locate Langford, who had traveled to Tau Volantis, one of Earth's oldest off-world colonies, in search of the true origins of the Markers and a means to stop the Necromorph scourge once and for all.

Rumors of a revival of Dead Space within EA appeared in early 2021. Venture Beat reported in July that this revival was a remake of the first game, in the same vein as the Resident Evil 2 remake, and would be a relaunch of the franchise. EA confirmed the remake of Dead Space, under development by Motive Studio, in their EA Play event the same month. It was released on January 27, 2023.

A prequel to the first Dead Space, Dead Space: Extraction follows a group of colonists from the Aegis VII colony who are beset by Necromorphs created when the Red Marker is removed. Originally released as a rail shooter title for the Nintendo Wii in 2009, a port with PlayStation Move support for the PlayStation 3 was later released as a downloadable game on the PlayStation Network in 2011. It was also bundled with copies of the limited editions of Dead Space 2 for the PlayStation 3.