Pofi is a comune (municipality) of about 4,200 inhabitants in the province of Frosinone in the Italian region Lazio, located about 80 kilometres (50 mi) southeast of Rome and about 9 kilometres (6 mi) southeast of Frosinone.

Pofi borders the following municipalities: Arnara, Castro dei Volsci, Ceccano, Ceprano, Ripi. It is located on an extinct volcano, near the Sacco river valley. Sights include the church of Sant'Antonino Martire (11th century).