The Popular Resistance Committees (PRC; Arabic: لجان المقاومة الشعبية, Lijān al-Muqāwama al-Shaʿbiyya) is a coalition of a number of armed Palestinian groups opposed to what they regard as the conciliatory approach of the Palestinian Authority and Fatah towards Israel.

The PRC is especially active in the Gaza Strip, through its military wing, the Al-Nasser Salah al-Deen Brigades. The PRC has planned and executed a number of varied operations, but specializes in planting roadside bombs and vehicle explosive charges - directed against military and civilian convoys.

Formed in late 2000 by former Fatah and Tanzim member Jamal Abu Samhadana, the PRC is composed primarily of ex-Fatah fighters and Al-Aqsa Martyrs' Brigades members and is alleged by Israel to be inspired and financed by Hezbollah. The present leader of PRC is Ayman al-Shashniya.

The PRC was believed to be the third strongest faction active in the Gaza Strip, after Hamas and Islamic Jihad in 2012. It is currently fighting alongside Hamas and other allied Palestinian factions in the ongoing Gaza war (2023–present). It has been designated a terrorist organization by Israel and the United States.

The PRC was formed in late 2000 by former Fatah and Tanzim member Jamal Abu Samhadana, and is composed primarily of ex-Fatah fighters and al-Aqsa Martyrs' Brigades members.

On 15 October 2003, explosives destroyed a US diplomatic convoy at Beit Hanoun, killing three security guards and severely wounding a diplomat. The PRC initially claimed responsibility for the attack, but later denied carrying out the attack, saying it was against Palestinian interests. The US demanded that the Palestinian National Authority find those responsible and bring them to justice. Palestinian officials said that because of lack of progress in the attack investigation, the US halted financial support for the PA and placed unofficial sanctions on its accounts. After heavy US pressure, the Palestinian Authority arrested several PRC members, accusing them of being responsible. The PRC confirmed the men were PRC members. The PA tried the four "suspects" in a Palestinian military court, but intelligence agencies dismissed the tribunal as a "mock trial" and said while the suspects were PRC activists, they were not those responsible for the attack. The men were released in March 2004.

The Jenin Martyr's Brigade was formed in March 2003 as a part of the PRC. Besides other activities, the JMB claimed responsibility for the March 2003 bombing of an Israeli bus in Haifa. The bus was blown to pieces when a suicide bomber, seated in the rear of the vehicle, detonated 10-15 kilograms of shrapnel-laced explosives that were attached to his body. 16 people died in the blast, and another 30-40 were injured. On 17 July 2004, the group kidnapped Palestinian Civil Police Forces Chief Ghazi al-Jabali at gunpoint in an ambush of his convoy which wounded two bodyguards. Al-Jabali was only released after Palestinian President Yasser Arafat agreed to PRC demands that he be fired.

The PRC are also involved in Rafah's smuggling tunnels which have been used to smuggle weapons, explosives, fugitives and civilian supplies etc.