Portfolio: An Intercontinental Quarterly was a cross-disciplinary literary journal published between 1945 and 1947. It was edited by Caresse Crosby and published through her Black Sun Press. Only six issues were published, each totaling about 1000 copies. Each issue was a series of loose sheets contained in a folio, lavishly illustrated, and printed in limited numbers. Contributors included many avant-garde authors, architects, photographers, and illustrators who were prominent in their respective fields, including individuals like Albert Camus (who contributed "Letter to a German Friend," his first appearance in an English-language publication), architect Luigi Moretti, artist Pablo Picasso, and photographer Henri Cartier-Bresson, along with emerging writers like Charles Bukowski. It introduced American readers to many authors who later became famous.

Caresse Crosby, a long-time patron of the arts, originally published with her husband Harry Crosby through the Black Sun Press a number of emerging writers during the 1920s and 1930s in Paris. After his suicide in December 1929, she continued their work, though less actively. The press stopped active publishing when World War II intervened and Crosby left Paris for the United States.

Towards the end of World War II, Harry T. Moore encouraged her to start a new cultural magazine, which she titled Portfolio with the desire to present to the public "lively and varied examples of work by modern artists." Each issue contained prose, poetry, prints and plans. She hoped to initiate an "exchange of thought between America and Europe" and to carry forth "a new expression of man's aspirations." She followed in the tradition of the original literary journal transition, which her husband Harry Crosby had edited. She hoped that artists of all kinds could "build a bridge of enduring fabric between the ivory tower and the arena" and contribute to rebuilding the culture of Europe. The Portfolios included work by a variety of avant-garde writers, artists, photographers, and architects. The publication featured new work, translated works of foreign writers, re-published works of writers whose work had not been widely known, and both original images and reproductions of various artist's work.

During World War II and for some time after, paper was in short supply. Caresse printed the magazine on a variety of different sizes, colors and types of paper stock printed by different printers, stuffed into a 11.5 by 15 inches (290 mm × 380 mm) folio, though the size varied. Caresse printed 1,000 copies of each issue, and as she had done with earlier works published by the Black Sun Press, gave special treatment to 100 or so deluxe copies that featured original artwork by Henri Matisse, Romare Bearden, and others. Crosby worked from her offices at 1620 20th Street NW in Washington D.C. She lived around the corner at 2008 Q St. NW. She later moved the offices to 918 F Street, N.W.

Only six issues were published. Issues 1, 3, and 5 were printed in Washington, D.C. Issue 2 was printed in Paris less than seven months after the end of World War II. It featured primarily French writers and artists. The fourth issue was published in Rome and featured Italian writers and artists. The last issue, number 6, was published in Athens and focused on Greek authors and artists.

Crosby intended to publish four issues per year, and initially offered subscriptions for US$10.00 per year. Single copies were available for $3.00 each. She originally intended to print only 1,300 copies of each issue, but in fact printed only 1000 copies of each issue.

The inaugural issue was published in Washington, D.C., in 1945, immediately after the end of World War II. It included 26 leaves in loose sheets, contained in a paper folio cover. Edited by Caresse Crosby. Harry T. Moore served as assistant editor. Editorial advisers were Henry Miller for prose, Selden Rodman for poetry, and Sam Rosenberg for photography.

Prose was contributed by Caresse Crosby, René Crevel, Henry Miller (The Stuff of Life), David Daiches, Jerome Weidman (Sam). Poetry contributors included Karl Shapiro who contributed three sonnets from the Place of Love; Kay Boyle, Louis Aragon, Ruth Herschberger, Demetrios Capetanakis (Emily Dickinson) and Coleman Rosenberger, who wrote Manet in the Sale Mines at Merkers and also served as an editorial adviser.