Prairie College is an interdenominational Christian College located in the town of Three Hills, Alberta, Canada. Founded as Prairie Bible Institute, classes began on October 9, 1922, on the property of the McElheran family farm.

A local Bible Study group led by J. Fergus Kirk, a central Alberta Presbyterian farmer, was the precursor to Prairie College. Kirk asked W.C. Stephens, the principal of the Midland Bible Institute of Kansas City, a short-lived school of the Christian and Missionary Alliance, to send a teacher north west to the Canadian prairies. As a result, L. E. Maxwell arrived in Three Hills in the fall of 1922 and immediately proceeded to teach and eventually develop a structured curriculum. Maxwell became the school's principal and later its president. After 58 years, Maxwell retired in the spring of 1980 near the age of 85. The current president of Prairie College is Mark Maxwell, L. E. Maxwell's grandson.

Maxwell, the Kirks, the McElherans, and other local families saw the school grow to attain an enrolment of over 900 students by 1948 and become Canada's largest Bible college, a position it would hold until 1984. Although initially wary of outside alliances and influences, Prairie Bible Institute was officially incorporated and eventually accredited to grant degrees in divinity through provincial legislative acts and amendments of The Crown in Right of Alberta, and has conferred associate's degrees and Bachelor degrees to its graduates since 1980. From 1988 to 2004, PBI operated a graduate school and offered Master's degrees at a satellite campus in Calgary. During that same period, PBI reached undergraduate credit and programmatic block transfer arrangements with The King's University College in Edmonton and the University of Lethbridge in southern Alberta, and became accredited in 1997 when the Association for Biblical Higher Education accepted PBI as a full member.

Graduate level education returned to Prairie in the fall of 2012 through reciprocal academic arrangements with Carey Theological College, an accredited seminary affiliated with the University of British Columbia of Vancouver. In that agreement, fourth year students in PBI's baccalaureate programs were eligible to receive one year's advanced standing toward a master's degree at Carey. Alternatively, a student could enrol directly in Carey's seminary courses after completing three academic years at Prairie, and have those graduate credits fulfill both fourth year bachelor's degree requirements at Prairie College, as well as first-year course requirements in one of Carey's graduate programs.

Additionally in 2019, Prairie College entered into a full partnership with Taylor Seminary of Edmonton, Alberta to deliver accelerated hybrid B.A.M., M.Div. concurrent degrees that Prairie College students are able to achieve within five academic years through an integrated program of studies. This agreement lapsed when Taylor pursued status as a legacy campus of Kairos University. However, Carey Theological College and Prairie College enhanced their partnership with a hybrid/online accelerated five-year B.A.M., M.Div. - available to students around the world.

In 2020, Prairie College introduced a new master's degree program in Global Leadership in Christian Education.

Ventures initiated by Prairie were the Prairie Sunday School Mission, established in 1929, which was subsequently reorganized as the Alberta branch of the Canadian Sunday School Mission - later renamed as One Hope Canada. In 1933, at the invitation of Peace River area residents, Prairie College graduate Walter W. McNaughton traveled from Viking, Alberta, to Peace River country to establish the Peace River Bible Institute, now located at Sexsmith, near the city of Grande Prairie. By the 1940s, Prairie had founded three general education Christian schools on its Three Hills campus: Prairie Elementary, Prairie Junior High, and Prairie High School. In 2004 these schools were amalgamated as Prairie Christian Academy (PCA) and began to operate independently from the Bible Institute. PCA now exists as one of Alberta's alternative schools under the local public school division.

Another outgrowth of the school was its own campus church, The Prairie Tabernacle Congregation. This fellowship met for more than fifty years in a cavernous auditorium seating 4,300. Remodeled and renamed in 1985, the Maxwell Memorial Tabernacle was Canada's largest religious auditorium. In 2005, the building was demolished so that a new multipurpose facility, The Maxwell Centre, could be built to house administrative offices and classrooms for Prairie College. As for Prairie Tabernacle Congregation, the fellowship initially moved its meeting place to the local Christian Academy and subsequently migrated to other facilities on the college campus. In January 2020, a new Prairie Tabernacle was officially opened for the congregation. This modern facility contains 17,000 square feet and is located on Highway 583 adjacent to the Prairie Christian Academy. It stands about 5 blocks east of the Prairie College campus.