Precious Pupp is an American animated television series produced by Hanna-Barbera Productions that aired as a segment on The Atom Ant/Secret Squirrel Show from October 2, 1965, to September 7, 1967.

The cartoon featured a large mangy dog named Precious Pupp, voiced by Don Messick, and his owner Granny Sweet, voiced by Janet Waldo. Granny was a kindly woman with a passion for motorcycles, completely oblivious to the fact that her beloved, affectionate pet was something of a neighborhood terror. He had a habit of slipping behind a victim quietly – sometimes in defense of their home, sometimes just for the fun of it – and jolting him with a ferocious series of barks... but never where or when Granny could catch him in the act.

Unlike many cartoon animals, Precious did not speak. His usual vocalism was an asthmatic-sounding, "wheezing" laugh used even more famously by Muttley, a Hanna-Barbera character introduced three years later. He usually outsmarted his enemies, most notably Bruiser, the neighborhood bulldog, but he also usually outsmarted his oblivious owner, too.

Twenty-six episodes were produced.