Mauricio Macri's tenure as the president of Argentina began on 10 December 2015, and ended on 10 December 2019. Macri, a member of the Republican Proposal, took office after defeating the Justicialist candidate, Daniel Scioli, in the 2015 general election. He is Argentina's first democratically elected non-Radical or Peronist president since 1916. Macri unsuccessfully sought re-election in the 2019 general election, losing to Alberto Fernández and becoming the first incumbent president in Argentina and South America's history to be unseated by a challenger and not reach a second term.

He promised to reduce inflation, improve conditions for business, and cease the international alignment with Venezuela and Iran. Macri has announced an infrastructure development strategy named Plan Belgrano (after Manuel Belgrano), a plan aimed at building infrastructure and encouraging industry development in ten of Argentina's northern provinces, which have historically lagged behind the rest of the country in these areas. The plan includes a proposed investment of equivalent to 16 billion United States dollars over the course of 10 years, along with an "historical reconstruction fund" of 50 billion pesos to be used in 4 years. Other objectives of the plan include the provision of housing for some 250,000 families, and the construction of 1400 child care centers.

Macri announced the full composition of his cabinet on 25 November 2015, some two weeks before he was due to take office.

Macri took office on 10 December 2015. He began the ceremony starting from his apartment in the neighborhood of Recoleta at the corner of Avenida del Libertador and Cavia at 11:00 pm to the National Congress of Argentina with his wife Juliana Awada and his youngest daughter of 4 years old, through the Casa Rosada and the Plaza de Mayo. At 11:41 he entered the room where the Legislature was, taking an oath after the Vice President Gabriela Michetti. Then he delivered a speech of 27 minutes in which he pledged his "support for an independent judiciary, fight corruption and drug trafficking, the internal union of Argentina, universal social protection, create a 21st-century style of education and that everyone can have a roof, water and sewer". Also greeted his competitors during the presidential elections.

Later he went to the Casa Rosada, where he received the presidential attributes in the White Hall of the hands of the Temporary President of the Senate, Federico Pinedo, accompanied by Vice President Gabriela Michetti, president of the Chamber of Deputies Emilio Monzó and President of the Supreme Court Ricardo Lorenzetti. Minutes later came the historic balcony where thousands of people waited in the Plaza de Mayo, expressing his hope that "the Argentines can live better, starting a wonderful time for our country, always telling the truth, being honest, showing the problems " and calling " the Argentines to accompany management and alerting when he mistake".

After being anointed President, he gave a reception at the San Martín Palace of Argentina Foreign Ministry to all the heads of state present: Michelle Bachelet from Chile, Horacio Cartes from Paraguay, Juan Manuel Santos from Colombia, Rafael Correa from Ecuador, Evo Morales from Bolivia, Dilma Rousseff from Brazil, and representatives of other countries attending his inauguration.

One of the first changes to economic policy from the Macri administration, just seven days after he had taken office, was to remove the capital controls that had been in place for four consecutive years. The move signified a 30% devaluation of the peso, and was met with both criticism and praise.

The Macri's administration eliminated export taxes on agricultural products (wheat, corn, sunflower, meat and fish), minerals (metallic and non-metallic) and certain industrial products; while it promised to lower the tariff on soy 5% every year.