The prime minister of Croatia, officially the president of the government of the Republic of Croatia (Croatian: Predsjednik / Predsjednica Vlade Republike Hrvatske), is Croatia's head of government, and is de facto the most powerful and influential state officeholder in the Croatian system of government. Following the first-time establishment of the office in 1945, the 1990–2000 semi-presidential period is the only exception where the president of Croatia held de facto executive authority. In the formal Croatian order of precedence, however, the position of prime minister is the third highest state office, after the president of the Republic and the speaker of the Parliament.

The Constitution of Croatia prescribes that "Parliament supervises the Government" (Article 81) and that "the President of the Republic ensures the regular and balanced functioning and stability of government" (as a whole; Article 94), while the Government is introduced in Article 108. Since 2000, the prime minister has had various added constitutional powers and is mentioned before the Government itself in the text of the Constitution, in Articles 87, 97, 99, 100, 101, 103, 104. The current prime minister of Croatia is Andrej Plenković. The Government of Croatia meets in Banski dvori, a historical building located on the west side of St. Mark's Square in Zagreb.

The official name of the office, literally translated, is "President of the Government" (Predsjednik / Predsjednica Vlade), rather than a literal translation of "Prime Minister" (Prvi Ministar). In Croatian, the shorter term Premijer / Premijerka (Premier) is commonly used as well.

The Royal Government of the Kingdom of Croatia-Slavonia (1868–1918) was headed by the Ban of Croatia (Viceroy), who represented the King.

The first head of government of Croatia as a constituent republic of Federal People's Republic of Yugoslavia was Vladimir Bakarić, who assumed the position on 14 April 1945. The position was then the most powerful public office in the state in addition to the position of the Secretary of the League of Communists of Croatia, as a single-party system was in place. The head of government was renamed to the President of the Executive Council in 1952. Notably, Savka Dabčević-Kučar was the first woman (not only in Croatia, but in Europe) to hold an office equivalent to a head of government as Chairman of the Executive Council of the Socialist Republic of Croatia (1967–1969).

After the constitutional amendments that allowed for multi-party elections in Croatia in 1990, the country was still a constituent republic of SFR Yugoslavia, the position of the President of the Executive Council of the Socialist Republic of Croatia was filled by Stjepan Mesić on 30 May 1990 (the 14th Executive Council).

The newly-elected Croatian Parliament enacted numerous amendments to the constitution on 25 July 1990. It eliminated socialist references and adopted new national symbols, while the Government of the Republic of Croatia was formally instituted by Amendment LXXIII.

The Constitution of Croatia was subsequently also changed significantly on 22 December 1990, as the so-called "Christmas Constitution" fundamentally defined the Republic of Croatia and its governmental structure. From this point onwards, Croatia was a semi-presidential republic, which meant the president of Croatia had broad executive powers (further expanded with laws to a point of superpresidentialism), including the appointment and dismissal of the prime minister and other officials in the government.