Pristinailurus bristoli is a fossil species in the carnivoran family Ailuridae. It is well-represented in the Hemphillian-aged deposits at the Gray Fossil Site in Gray, Tennessee. It was significantly larger than the living Ailurus, but probably possessed a comparatively weaker bite. P. bristoli was sexually dimorphic, as males appeared to have been up to twice the size of females.

P. bristoli was likely adapted to terrestrial and some arboreal locomotion, with a generalist diet.