Priyamvada "Priya" Natarajan is a theoretical astrophysicist, Chair of the department of astronomy and professor of physics at Yale University. She is noted for her work in mapping dark matter and dark energy, particularly in gravitational lensing and in models describing the assembly and accretion histories of supermassive black holes. She authored the book Mapping the Heavens: The Radical Scientific Ideas That Reveal the Cosmos. She has been featured on shows such as Black Hole Apocalypse on PBS, showcasing her work and background.

Priya Natarajan was born in Coimbatore, Tamil Nadu in India to academic parents. She grew up in New Delhi, where she would visit Nehru Planetarium Delhi and had a great interest in celestial and terrestrial maps as a kid. Her parents bought her a telescope and microscope as a child, to which she commented: "it was very clear to me that it was the telescope." During her high school education, her father gifted her a computer, Commodore 64 (personal computers were not known in India at the time), for mapping the night sky, which inspired her later education, career and writing a book Mapping the Heavens: The Radical Scientific Ideas That Reveal the Cosmos, published in 2016.

In 1984, Natarajan enrolled herself in an amateur astronomy club based at the Nehru Planetarium in New Delhi. She told the then-director of the planetarium Nirupama Raghavan that she owned a personal computer and asked for a research project. Raghavan immediately assigned her to plot the whole night sky over New Delhi. Within six weeks Natarajan self-taught spherical geometry and developed the technique to map the night sky. Two years later, she completed the project, to which Raghavan commented that she had become a "real scientist." She studied at St. Thomas's School before completing her schooling at Delhi Public School.

Natarajan has undergraduate degrees in physics and mathematics from M.I.T (1986-1991). She was awarded a Master of Science from the Program in Science, Technology & Society at the Massachusetts Institute of Technology, Cambridge, MA (1991-1994). She continued for a Ph.D. programme and started researching on the history and philosophy of science focussing on cosmology. After three years she met German astronomer Martin Schwarzschild who understood her capacity in astronomy and persuaded her to change her study to theoretical astrophysics. She later recalled: "I never really went back to finish that first PhD!"

With the Isaac Newton Fellowship from the University of Cambridge, Natarajan moved to England for a fresh doctoral course to work with Martin Rees at the Institute of Astronomy, on supermassive black holes. She received a Ph.D. degree in 1998. There she was a member of Trinity College and was elected to a Title A Research Fellowship that she held from 1997 to 2003. She was the first woman astrophysicist elected as a Fellow at Trinity College. Prior to going to Yale, she was a visiting postdoctoral fellow at the Canadian Institute for Theoretical Astrophysics in Toronto, Canada.

Natarajan joined the faculty of Yale University in 2000 and later promoted to professor of astronomy and physics. She had served as Chair of the National Astronomy and Astrophysics Advisory Committee that advises NASA, NSF and DoE; as Chair of the Division of Astrophysics of the American Physical Society. As of 2024, she was a Joseph S. and Sophia S. Fruton Professor and Chair of Astronomy. As of 2025, she is director of the Franke Program in Science and the Humanities.

Natarajan held a Whitney Humanities Fellowship at Yale (2006–2007) and was the Emeline Conland Bigelow Fellow at the Radcliffe Institute for Advanced Study at Harvard (2008–2009). She was awarded a Guggenheim Fellowship in 2009.

Natarajan's research spans two main areas: mapping dark matter using gravitational lensing, and the formation and growth of supermassive black holes across cosmic time.