Progress MS-10 (Russian: Прогресс МC-10), identified by NASA as Progress 71P, was a Progress spaceflight operated by Roscosmos to resupply the International Space Station (ISS). This was the 162nd flight of a Progress spacecraft.

The Progress-MS is an uncrewed freighter based on the Progress-M featuring improved avionics. This improved variant first launched on 21 December 2015. It has the following improvements:

In 2014, the launch was expected on 22 February 2018. In 2017, the mission had slipped to August 2018. In June 2018, the launch was scheduled for 31 October 2018, but in the wake of the Soyuz MS-10 accident it had to be postponed on 16 November 2018.

Progress MS-10 launched atop a Soyuz-FG rocket on 16 November 2018, at 18:14:08 UTC from the Baikonur Cosmodrome in Kazakhstan.

Progress MS-10 docked as scheduled with the aft docking port of the Zvezda module on 18 November 2018 at 19:31:38 UTC.

The Progress MS-10 spacecraft delivered 2,564 kg of cargo and supplies to the International Space Station. The following is a breakdown of cargo bound for the ISS:

It undocked at 08:40 UTC and deorbited in Pacific Ocean, on 4 June 2019 at 11:28 UTC.