The nineteenth season of Project Runway began Thursday, October 14, 2021. Sixteen designers competed to become "the next great American designer." Elle editor-in-chief Nina Garcia, fashion designer Brandon Maxwell, and former Teen Vogue editor-in-chief and journalist Elaine Welteroth returned as judges. Season 4 winner Christian Siriano returned to mentor the designers and use the "Siriano Save" to bring an eliminated designer back into the competition if he disagrees with the judges' verdict. Karlie Kloss did not return as host and head judge but appeared in the penultimate episode of the season as a guest judge.

The winner of the season was Shantall Lacayo from Miami, Florida. Lacayo marked the first time a contestant from an international spin-off participated and won in the original U.S. franchise, having previously competed and finished in third on the first season of Project Runway Latin America. This season brought in four women to the finale, with Chasity Sereal, Coral Castillo, and Kristina Kharlashkina finishing as runners-up.

Anna Yinan Zhou and Prajjé Oscar Jean-Baptiste competed later on season 20 with Anna placing 8th and Prajjé placing 5th out of 14.

^*Shantall Lacayo was a finalist on Project Runway Latin America season 1.

^Note 1 Due to mental health reasons, Meg withdrew from the competition, sparing Darren, Katie, and Kenneth from possible elimination.

^Note 2 Although Katie was deemed safe, the judges let her know they loved her look.

^Note 3 : Despite two designers being marked safe, every designer was given a critique.

^1 Female, male, and non-binary models were used for this challenge.